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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal myocardial fiber physiology
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Accession:MP:0004215 term browser browse the term
Definition:anomaly in the function of the terminally differentiated, non-proliferative, multinucleated muscle cells of the heart
Synonyms:exact_synonym: abnormal adult cardiomyocyte physiology;   abnormal cardiac muscle cell physiology;   abnormal cardiac myocyte physiology;   abnormal myocardial fibre physiology


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abnormal myocardial fiber calcium currents term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh7b myosin heavy chain 7B IMP RGD PMID:32207065 RGD:126925946 NCBI chr 3:144,076,911...144,122,714
Ensembl chr 3:144,098,190...144,122,084 		JBrowse link
G Myh7bem1Blar myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar IMP RGD PMID:32207065 RGD:126925946
decreased cardiomyocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl2 interleukin 1 receptor-like 2 IMP compared to Wild Type in cardiopulmonary bypass model RGD PMID:32048631 RGD:126925167 NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667 		JBrowse link
G Il1rl2tm1(Myh6-cre)Mhzh interleukin 1 receptor-like 2; tm1 (Myh6-cre), Mhzh IMP compared to Wild Type in cardiopulmonary bypass model RGD PMID:32048631 RGD:126925167
increased cardiomyocyte apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A IMP mRNA:incr expr:myocardium (rat) RGD PMID:30887465 RGD:151665136 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Ubd ubiquitin D IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Ubdem1 ubiquitin D; CRISPR/Cas9 induced mutant1 IMP associated with induced myocardial infarction RGD PMID:29438664 RGD:126925221
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5373
    cardiovascular system phenotype 1356
      abnormal cardiovascular system physiology 1132
        abnormal myocardial fiber physiology 11
          abnormal cardiomyocyte apoptosis + 7
          abnormal myocardial fiber currents + 4
          decreased calcium uptake by cardiac muscle 0
          increased calcium uptake by cardiac muscle 0
          myocardium degeneration 0
paths to the root