MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: increased cholesterol level
Accession: MP:0003982
browse the term
Definition: greater than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
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Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
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Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
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Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:28124283
RGD:13703118
NCBI chr X:124,722,628...124,766,079
Ensembl chr X:124,722,628...124,766,044
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Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
RGD
PMID:28124283
RGD:13703118
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Lep
leptin
IMP
DNA:nonsense mutation:cds:
RGD
PMID:23800849
RGD:8549777
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lepm1Kyo
leptin; ENU induced mutant1, Kyo
IMP
RGD
PMID:23800849
RGD:8549777
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Lepr
leptin receptor
disease_progression
IMP IAGP
RGD
PMID:27225180 , PMID:27465994 , PMID:26537785 , PMID:23154293
RGD:12910507 , RGD:12911217 , RGD:12911216 , RGD:13432147
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
disease_progression
IMP
RGD
PMID:27465994
RGD:12911217
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Leprem3
leptin receptor; TALEN induced mutant 3
IMP
RGD
PMID:27225180
RGD:12910507
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Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
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Leprfa
leptin receptor; fa mutant
IAGP
RGD
PMID:23154293
RGD:13432147
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Lrrk2
leucine-rich repeat kinase 2
IMP
RGD
PMID:24244710 , PMID:23799078
RGD:12880447 , RGD:13462048
NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
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Lrrk2em1Sage
leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
RGD
PMID:24244710
RGD:12880447
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Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
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Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
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Lep
leptin
IMP
RGD
PMID:22948215
RGD:12904911
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lepem1Sage
leptin; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:22948215
RGD:12904911
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Lepr
leptin receptor
IMP
RGD
PMID:26537785
RGD:12911216
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
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Lep
leptin
IMP
RGD
PMID:22948215
RGD:12904911
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lepem1Sage
leptin; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:22948215
RGD:12904911
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Lepr
leptin receptor
IMP
RGD
PMID:26537785
RGD:12911216
NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Leprem4Lizh
leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
IMP
compared to wild type littermate
RGD
PMID:26537785
RGD:12911216
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Atp7b
ATPase copper transporting beta
IAGP
RGD
PMID:17303181
RGD:2292672
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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Atp7bhts
ATPase copper transporting beta; hepatitis
IAGP
RGD
PMID:17303181
RGD:2292672
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Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
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