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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal lymphocyte physiology
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Accession:MP:0003945 term browser browse the term
Definition:any functional anomaly of any of the white blood cells that includes B cells, T cells, and NK cells


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decreased IgA level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgE level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgG level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased IgM level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ighm immunoglobulin heavy constant epsilon IMP RGD PMID:21038471 RGD:150523760 Ensembl chr 6:132,329,269...133,053,426 JBrowse link
G Ighmem1Ang immunoglobulin heavy constant mu; ZFN induced mutant1, Ang IMP RGD PMID:21038471 RGD:150523760
G Ighmem2Ang immunoglobulin heavy constant mu; ZFN induced mutant2, Ang IMP RGD PMID:21038471 RGD:150523760
decreased immunoglobulin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
decreased T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd247 Cd247 molecule IMP compared to wild-type RGD PMID:24343121 RGD:13442481 NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263 		JBrowse link
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:24343121 RGD:13442481
impaired natural killer cell mediated cytotoxicity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
increased T cell apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 IMP compared to SD RGD PMID:30262871 RGD:45073131 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon1em1Lizh paraoxonase 1; CRISPR/Cas9 induced mutant 1, Lizh IMP compared to SD RGD PMID:30262871 RGD:45073131
increased T cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Themis thymocyte selection associated IAGP DNA:frameshift mutation: RGD PMID:22275874 RGD:38599149 NCBI chr 1:16,433,906...16,623,889
Ensembl chr 1:16,432,631...16,664,329 		JBrowse link
G Themism1Adej thymocyte selection associated; mutant1, Adej IAGP compared to BN RGD PMID:22275874 RGD:38599149
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    immune system phenotype 502
      abnormal immune system physiology 384
        abnormal immune cell physiology 56
          abnormal leukocyte physiology 56
            abnormal lymphocyte physiology 49
              abnormal B cell physiology + 31
              abnormal NK cell physiology + 5
              abnormal T cell physiology + 14
              abnormal lymphocyte activation involved in immune response + 1
paths to the root