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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal microglial cell physiology
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Accession:MP:0003691 term browser browse the term
Definition:any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques



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abnormal microglial cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
increased microglial cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5415
    nervous system phenotype 377
      abnormal nervous system physiology 218
        abnormal glial cell physiology 3
          abnormal microglial cell physiology 3
            abnormal microglial cell activation + 3
            abnormal microglial cell chemotaxis 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5415
    hematopoietic system phenotype 250
      abnormal hematopoietic system physiology 62
        abnormal blood cell physiology 60
          abnormal leukocyte physiology 56
            abnormal macrophage physiology 5
              abnormal microglial cell physiology 3
                abnormal microglial cell activation + 3
                abnormal microglial cell chemotaxis 0
paths to the root