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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:thymus atrophy
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Accession:MP:0003644 term browser browse the term
Definition:acquired diminution of the size of the thymus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
Synonyms:exact_synonym: atrophic thymus;   atrophied thymus;   thymic atrophy
 xref: EFO:0009875


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thymus atrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase IAGP MGI PMID:2065352 PMID:20980600 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Aire autoimmune regulator IAGP MGI PMID:11854172 NCBI chr10:77,865,856...77,879,444
Ensembl chr10:77,865,856...77,879,444 		JBrowse link
G Apex2 apurinic/apyrimidinic endonuclease 2 IAGP MGI PMID:15319281 NCBI chr  X:149,286,625...149,371,175
Ensembl chr  X:149,302,515...149,372,864 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 IAGP MGI PMID:7812968 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bmi1 Bmi1 polycomb ring finger oncogene IAGP MGI PMID:22185780 NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440 		JBrowse link
G Braf Braf transforming gene IAGP MGI PMID:21383153 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit IEA MGI NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Cbx4 chromobox 4 IAGP MGI PMID:23362346 NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047 		JBrowse link
G Cd2ap CD2-associated protein IAGP MGI PMID:10514378 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556 		JBrowse link
G Cdk6 cyclin dependent kinase 6 IAGP MGI PMID:19155308 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Commd10 COMM domain containing 10 IAGP MGI PMID:22185780 NCBI chr18:47,091,917...47,242,435
Ensembl chr18:47,091,883...47,367,351 		JBrowse link
G Ctsd cathepsin D IAGP MGI PMID:26232697 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsl cathepsin L IAGP MGI PMID:10199917 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cycs cytochrome c, somatic IAGP MGI PMID:15907471 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Dab1 disabled 1 IEA MGI NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Dhrs7b dehydrogenase/reductase 7B IEA MGI NCBI chr11:60,721,457...60,749,249
Ensembl chr11:60,721,457...60,751,021 		JBrowse link
G Edil3 EGF-like repeats and discoidin I-like domains 3 IAGP MGI PMID:26232697 NCBI chr13:88,969,591...89,471,344
Ensembl chr13:88,969,591...89,471,342 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 IAGP MGI PMID:9756641 NCBI chr 2:180,783,551...180,798,808
Ensembl chr 2:180,789,446...180,798,807 		JBrowse link
G Fas Fas cell surface death receptor IAGP MGI PMID:309911 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fbxo7 F-box protein 7 IAGP MGI PMID:30840666 NCBI chr10:85,856,313...85,887,737
Ensembl chr10:85,857,836...85,887,737 		JBrowse link
G Fen1 flap structure specific endonuclease 1 IAGP MGI PMID:12119409 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533 		JBrowse link
G Fgf23 fibroblast growth factor 23 IAGP MGI PMID:14966565 NCBI chr 6:127,049,865...127,059,257
Ensembl chr 6:127,049,865...127,058,371 		JBrowse link
G Foxn1 forkhead box N1 IAGP MGI PMID:19955175 NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384 		JBrowse link
G Fzd9 frizzled class receptor 9 IAGP MGI PMID:15572594 NCBI chr 5:135,277,792...135,279,901
Ensembl chr 5:135,277,792...135,280,084 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IAGP MGI PMID:20190135 NCBI chr 6:48,723,131...48,731,134
Ensembl chr 6:48,723,131...48,731,144 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit IEA MGI NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:15784609 PMID:15882627 PMID:24498102 PMID:24557836 PMID:28846072 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hr lysine demethylase and nuclear receptor corepressor IAGP MGI PMID:10536052 PMID:15955095 NCBI chr14:70,789,644...70,810,988
Ensembl chr14:70,789,652...70,810,988 		JBrowse link
G Htra2 HtrA serine peptidase 2 IAGP MGI PMID:25531304 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Hydin HYDIN, axonemal central pair apparatus protein IEA MGI NCBI chr 8:110,993,600...111,336,885
Ensembl chr 8:110,993,609...111,336,885 		JBrowse link
G Ifng interferon gamma IAGP MGI PMID:25342713 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Kitl kit ligand IAGP MGI PMID:319242 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278 		JBrowse link
G Kl klotho IAGP MGI PMID:9363890 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:28846072 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Krt14 keratin 14 IAGP MGI PMID:23918954 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374 		JBrowse link
G Lmna lamin A IAGP MGI PMID:10579712 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 IAGP MGI PMID:17526734 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 IAGP MGI PMID:17526734 NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 IAGP MGI PMID:30254136 NCBI chr 2:25,134,825...25,145,458
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 IAGP MGI PMID:9314550 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha IAGP MGI PMID:7590249 PMID:11067893 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Parl presenilin associated, rhomboid-like IAGP MGI PMID:16839884 PMID:30578322 NCBI chr16:20,098,570...20,121,090
Ensembl chr16:20,098,568...20,121,137 		JBrowse link
G Prnp prion protein IAGP MGI PMID:16517717 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 IAGP MGI PMID:22590589 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 IAGP MGI PMID:664185 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B IAGP MGI PMID:7834753 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 IAGP MGI PMID:24557836 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
G Rnpc3 RNA-binding region (RNP1, RRM) containing 3 IAGP MGI PMID:30254136 NCBI chr 3:113,398,716...113,423,798
Ensembl chr 3:113,398,716...113,423,798 		JBrowse link
G Rora RAR-related orphan receptor alpha IAGP MGI PMID:1565842 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528 		JBrowse link
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) IAGP MGI PMID:15723268 NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IAGP MGI PMID:11371356 PMID:11606785 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IAGP MGI PMID:11371356 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:11371356 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Stk36 serine/threonine kinase 36 IAGP MGI PMID:16055717 NCBI chr 1:74,640,583...74,676,053
Ensembl chr 1:74,640,604...74,676,053 		JBrowse link
G Stub1 STIP1 homology and U-Box containing protein 1 IAGP MGI PMID:14532117 NCBI chr17:26,049,608...26,051,893
Ensembl chr17:26,049,479...26,052,378 		JBrowse link
G Supv3l1 suppressor of var1, 3-like 1 (S. cerevisiae) IAGP MGI PMID:19145458 NCBI chr10:62,265,000...62,287,294
Ensembl chr10:62,264,988...62,285,517 		JBrowse link
G Tcirg1 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 IAGP MGI PMID:15294947 NCBI chr19:3,946,050...3,957,717
Ensembl chr19:3,946,050...3,957,133 		JBrowse link
G Tdp2 tyrosyl-DNA phosphodiesterase 2 IAGP MGI PMID:23505375 NCBI chr13:25,015,642...25,026,136
Ensembl chr13:25,015,662...25,026,136 		JBrowse link
G Tle4 transducin-like enhancer of split 4 IAGP MGI PMID:25153823 NCBI chr19:14,425,434...14,575,542
Ensembl chr19:14,425,514...14,575,415 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 IAGP MGI PMID:24498102 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Tomm5 translocase of outer mitochondrial membrane 5 IAGP MGI PMID:22688586 NCBI chr 4:45,105,209...45,108,113
Ensembl chr 4:45,105,208...45,108,114 		JBrowse link
G Tpp2 tripeptidyl peptidase II IAGP MGI PMID:18362329 NCBI chr 1:43,973,130...44,042,160
Ensembl chr 1:43,972,807...44,042,160 		JBrowse link
G Traf2 TNF receptor-associated factor 2 IAGP MGI PMID:9390694 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Traf6 TNF receptor-associated factor 6 IAGP MGI PMID:14499111 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Twist2 twist basic helix-loop-helix transcription factor 2 IAGP MGI PMID:12553906 NCBI chr 1:91,729,183...91,775,756
Ensembl chr 1:91,729,183...91,775,750 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 IAGP MGI PMID:12665593 NCBI chr17:66,230,060...66,258,198
Ensembl chr17:66,228,967...66,258,221 		JBrowse link
G Wls wntless WNT ligand secretion mediator IAGP MGI PMID:23918954 NCBI chr 3:159,545,287...159,644,302
Ensembl chr 3:159,545,309...159,644,300 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 IAGP MGI PMID:20622884 NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787 		JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 IAGP MGI PMID:20622884 NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375 		JBrowse link
thymus cortex atrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin dependent kinase 6 IAGP MGI PMID:15315761 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 IAGP MGI PMID:25111180 NCBI chr 4:152,018,177...152,066,416
Ensembl chr 4:152,018,148...152,066,594 		JBrowse link
G Fas Fas cell surface death receptor IEA MGI NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fyn Fyn proto-oncogene IAGP MGI PMID:8562954 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gnas GNAS complex locus IAGP MGI PMID:9671744 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Hr lysine demethylase and nuclear receptor corepressor IAGP MGI PMID:7640630 NCBI chr14:70,789,644...70,810,988
Ensembl chr14:70,789,652...70,810,988 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 IAGP MGI PMID:30254136 NCBI chr 2:25,134,825...25,145,458
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 IAGP MGI PMID:8562954 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Rnpc3 RNA-binding region (RNP1, RRM) containing 3 IAGP MGI PMID:30254136 NCBI chr 3:113,398,716...113,423,798
Ensembl chr 3:113,398,716...113,423,798 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IAGP MGI PMID:9826711 PMID:10490099 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
thymus medulla atrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 (macrophage) IAGP MGI PMID:1887865 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 IAGP MGI PMID:30254136 NCBI chr 2:25,134,825...25,145,458
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034
Ensembl chr 2:25,134,833...25,146,034 		JBrowse link
G Rnpc3 RNA-binding region (RNP1, RRM) containing 3 IAGP MGI PMID:30254136 NCBI chr 3:113,398,716...113,423,798
Ensembl chr 3:113,398,716...113,423,798 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16965
    hematopoietic system phenotype 5543
      abnormal hematopoietic system morphology/development 5069
        abnormal thymus morphology 860
          abnormal thymus size 680
            small thymus 417
              thymus atrophy 74
                thymus cortex atrophy 10
                thymus medulla atrophy 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 16965
    immune system phenotype 5709
      abnormal immune system morphology 4077
        abnormal immune system organ morphology 2439
          abnormal thymus morphology 860
            abnormal thymus size 680
              small thymus 417
                thymus atrophy 74
                  thymus cortex atrophy 10
                  thymus medulla atrophy 3
paths to the root