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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal nervous system physiology
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Accession:MP:0003633 term browser browse the term
Definition:any functional anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions
Synonyms:narrow_synonym: abnormal brain function;   abnormal central nervous system physiology;   abnormal peripheral nervous system physiology;   central nervous system functional abnormalities;   central nervous system: other functional anomalies;   peripheral nervous system: functional anomalies
 alt_id: MP:0000945;   MP:0001887;   MP:0001910;   MP:0001918;   MP:0002155;   MP:0002158
 xref: MGI:2173615;   MGI:2173618

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      mammalian phenotype 16210
        nervous system phenotype 4437
          abnormal nervous system physiology 2591
            CNS inflammation + 74
            abnormal autonomic nervous system physiology + 57
            abnormal blood-brain barrier function + 32
            abnormal blood-cerebrospinal fluid barrier function 2
            abnormal blood-retina barrier function 4
            abnormal central pattern generator function + 20
            abnormal cerebrospinal fluid physiology + 10
            abnormal embryonic neuroepithelial cell proliferation + 19
            abnormal endoneurial fluid pressure + 0
            abnormal ependyma motile cilium physiology + 17
            abnormal glial cell physiology + 146
            abnormal glymphatic system physiology 0
            abnormal hippocampus physiology 9
            abnormal hypothalamus physiology + 34
            abnormal myelination + 241
            abnormal nervous system electrophysiology + 424
            abnormal nervous system regeneration + 25
            abnormal neuroendocrine gland physiology + 35
            abnormal neuron physiology + 807
            abnormal neuronal stem cell physiology + 17
            abnormal response to CNS ischemic injury + 104
            abnormal sensorimotor gating + 29
            abnormal somatic nervous system physiology + 99
            abnormal somatosensory cortex physiology + 7
            abnormal synaptic physiology + 1162
            abnormal tau protein phosphorylation + 0
            brain ischemia 8
            decreased hindbrain apoptosis 2
            encephalopathy 2
            endoneurial edema 0
            increased brain apoptosis + 55
            increased neural tube apoptosis + 47
            increased spinal cord apoptosis 9
            intracranial hemorrhage + 137
            nerve inflammation + 4
            seizures + 465
            spinal hemorrhage 26
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