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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal pancreatic alpha cell physiology
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Accession:MP:0003563 term browser browse the term
Definition:anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas
Synonyms:exact_synonym: abnormal glucagon secreting cell physiology;   abnormal pancreatic A cell physiology


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abnormal pancreatic alpha cell physiology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myt1 myelin transcription factor 1 IAGP MGI PMID:17928203 NCBI chr 2:181,405,099...181,469,579
Ensembl chr 2:181,405,125...181,469,590 		JBrowse link
abnormal glucagon secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit IAGP MGI PMID:15630454 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247 		JBrowse link
G Ffar1 free fatty acid receptor 1 IAGP MGI PMID:23403053 NCBI chr 7:30,559,993...30,560,895
Ensembl chr 7:30,556,815...30,560,989 		JBrowse link
decreased glucagon secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit IAGP MGI PMID:15777780 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac IAGP MGI PMID:15220195 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883 		JBrowse link
G Dbh dopamine beta hydroxylase IAGP MGI PMID:12959968 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IAGP MGI PMID:18845638 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:22764048 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,055,336 		JBrowse link
G Il6 interleukin 6 IAGP MGI PMID:18719127 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 IAGP MGI PMID:11319559 PMID:17503968 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Nkx2-2 NK2 homeobox 2 IAGP MGI PMID:9584121 NCBI chr 2:146,967,909...147,037,270
Ensembl chr 2:147,019,466...147,036,163 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IAGP MGI PMID:9192619 PMID:24456331 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Snap25 synaptosomal-associated protein 25 IAGP MGI PMID:17283335 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IAGP MGI PMID:18723011 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
increased glucagon secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 IAGP MGI PMID:26518685 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604 		JBrowse link
G Cadps Ca2+-dependent secretion activator IAGP MGI PMID:18177725 NCBI chr14:9,646,424...10,097,203
Ensembl chr14:9,646,684...10,097,200 		JBrowse link
G Cadps2 Ca2+-dependent activator protein for secretion 2 IAGP MGI PMID:18177725 NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420 		JBrowse link
G Gcgr glucagon receptor IAGP MGI PMID:23160527 NCBI chr11:120,420,011...120,429,815
Ensembl chr11:120,421,525...120,429,812 		JBrowse link
G Lepr leptin receptor IAGP MGI PMID:393618 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Mir375 microRNA 375 IAGP MGI PMID:19289822 NCBI chr 1:74,939,817...74,939,880
Ensembl chr 1:74,939,817...74,939,880 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IAGP MGI PMID:11781323 PMID:16123346 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Thra thyroid hormone receptor alpha IAGP MGI PMID:21914860 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tmem117 transmembrane protein 117 IAGP MGI PMID:37314252 NCBI chr15:94,527,066...94,993,978
Ensembl chr15:94,527,113...94,993,979 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein IAGP MGI PMID:15056606 NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549 		JBrowse link
increased pancreatic alpha cell proliferation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcgr glucagon receptor IAGP MGI PMID:23160527 PMID:32677665 NCBI chr11:120,420,011...120,429,815
Ensembl chr11:120,421,525...120,429,812 		JBrowse link
G Ins1 insulin I IAGP MGI PMID:11897712 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II IAGP MGI PMID:11897712 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IAGP MGI PMID:12933680 NCBI chr 2:143,388,053...143,658,204
Ensembl chr 2:143,388,076...143,658,205 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IAGP MGI PMID:18155690 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 IAGP MGI PMID:23160527 NCBI chr13:3,199,475...3,239,678
Ensembl chr13:3,236,206...3,239,317
Ensembl chr13:3,236,206...3,239,317 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17088
    endocrine/exocrine gland phenotype 3474
      abnormal gland physiology 927
        abnormal endocrine gland physiology 469
          abnormal endocrine pancreas physiology 251
            abnormal pancreatic alpha cell physiology 26
              abnormal glucagon secretion + 22
              increased pancreatic alpha cell proliferation 6
paths to the root