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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal intestinal goblet cell morphology
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Accession:MP:0003449 term browser browse the term
Definition:any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; the goblet cell is a highly polarized unicellular exocrine gland with the nucleus and other organelles concentrated at the base of the cell; the remainder of the cell's cytoplasm is occupied by membrane-bound secretory granules containing mucin; the goblet shape is due to the mucus laden granules in the apical part expanding, causing that part of the cell to balloon; the apical plasma membrane projects microvilli to give an increased surface area for secretion
Synonyms:broad_synonym: abnormal intestinal goblet cells


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abnormal intestinal goblet cell morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cplx1 complexin 1 IMP RGD PMID:31875236 RGD:127285808 NCBI chr14:1,184,677...1,216,392 JBrowse link
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Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    cellular phenotype 184
      abnormal cell morphology 47
        abnormal intestinal goblet cell morphology 1
          abnormal large intestine goblet cell morphology + 0
          abnormal small intestine goblet cell morphology + 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    digestive/alimentary phenotype 81
      abnormal digestive system morphology 59
        abnormal intestine morphology 19
          abnormal intestinal mucosa morphology 1
            abnormal intestinal goblet cell morphology 1
              abnormal large intestine goblet cell morphology + 0
              abnormal small intestine goblet cell morphology + 0
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