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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:neurofibrillary tangles
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Accession:MP:0003214 term browser browse the term
Definition:dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies
Synonyms:related_synonym: Alzheimer disease;   neuritic plaques;   senile plaques
 xref: HP:0002185;   HP:0002511


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neurofibrillary tangles term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S SHR-Tg(Thy1-MAPT)318 IMP RGD PMID:16753151 RGD:2290296
S SHR-Tg(Thy1-MAPT)72 IMP RGD PMID:16753151 RGD:2290296
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  mammalian phenotype 5420
    nervous system phenotype 376
      abnormal nervous system morphology 214
        nervous system inclusion bodies 10
          neurofibrillary tangles 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    nervous system phenotype 376
      abnormal nervous system morphology 214
        abnormal brain morphology 139
          brain lesion 15
            neurofibrillary tangles 2
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