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ONTOLOGY REPORT - ANNOTATIONS


Term:decreased insulin secretion
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Accession:MP:0003059 term browser browse the term
Definition:reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
Synonyms:exact_synonym: reduced insulin secretion


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decreased insulin secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 JBrowse link 7 46,104,523 46,180,039 RGD:5509061
G Abhd6 abhydrolase domain containing 6 JBrowse link 14 8,002,888 8,056,773 RGD:5509061
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:5509061
G Afmid arylformamidase JBrowse link 11 117,825,503 117,839,908 RGD:5509061
G Akap5 A kinase (PRKA) anchor protein 5 JBrowse link 12 76,324,617 76,334,517 RGD:5509061
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:5509061
G Akt2 thymoma viral proto-oncogene 2 JBrowse link 7 27,591,552 27,640,826 RGD:5509061
G Alb albumin JBrowse link 5 90,460,870 90,476,602 RGD:5509061
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 JBrowse link 4 45,799,022 45,804,608 RGD:5509061
G Alx3 aristaless-like homeobox 3 JBrowse link 3 107,595,031 107,605,875 RGD:5509061
G Ank2 ankyrin 2, brain JBrowse link 3 126,921,607 127,500,347 RGD:5509061
G Anxa7 annexin A7 JBrowse link 14 20,455,261 20,480,133 RGD:5509061
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 7 113,178,471 113,314,126 RGD:5509061
G Bad BCL2-associated agonist of cell death JBrowse link 19 6,941,861 6,951,905 RGD:5509061
G Bglap bone gamma carboxyglutamate protein JBrowse link 3 88,383,495 88,384,466 RGD:5509061
G Bglap2 bone gamma-carboxyglutamate protein 2 JBrowse link 3 88,377,736 88,378,701 RGD:5509061
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit JBrowse link 6 118,587,240 119,197,384 RGD:5509061
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit JBrowse link 14 30,039,941 30,491,156 RGD:5509061
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit JBrowse link 1 154,390,806 154,884,785 RGD:5509061
G Cadps Ca2+-dependent secretion activator JBrowse link 14 12,372,560 12,823,339 RGD:5509061
G Cadps2 Ca2+-dependent activator protein for secretion 2 JBrowse link 6 23,262,773 23,841,175 RGD:5509061
G Cartpt CART prepropeptide JBrowse link 13 99,898,483 99,910,179 RGD:5509061
G Cdh1 cadherin 1 JBrowse link 8 106,603,350 106,670,247 RGD:5509061
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 JBrowse link 13 29,191,746 29,855,683 RGD:5509061
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta JBrowse link 2 167,688,915 167,690,432 RGD:5509061
G Chgb chromogranin B JBrowse link 2 132,781,642 132,795,079 RGD:5509061
G Chrm3 cholinergic receptor, muscarinic 3, cardiac JBrowse link 13 9,875,486 10,361,062 RGD:5509061
G Cisd2 CDGSH iron sulfur domain 2 JBrowse link 3 135,406,412 135,424,039 RGD:5509061
G Clec16a C-type lectin domain family 16, member A JBrowse link 16 10,545,309 10,744,878 RGD:5509061
G Clock circadian locomotor output cycles kaput JBrowse link 5 76,209,868 76,305,603 RGD:5509061
G Col5a3 collagen, type V, alpha 3 JBrowse link 9 20,770,050 20,815,117 RGD:5509061
G E2f1 E2F transcription factor 1 JBrowse link 2 154,559,400 154,569,892 RGD:5509061
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha JBrowse link 12 78,862,072 78,887,010 RGD:5509061
G Ero1lb ERO1-like beta (S. cerevisiae) JBrowse link 13 12,565,818 12,609,533 RGD:5509061
G Esr2 estrogen receptor 2 (beta) JBrowse link 12 76,120,419 76,177,259 RGD:5509061
G Extl3 exostosin-like glycosyltransferase 3 JBrowse link 14 65,052,059 65,149,899 RGD:5509061
G Fam3b family with sequence similarity 3, member B JBrowse link 16 97,470,965 97,504,936 RGD:5509061
G Fem1b fem 1 homolog b JBrowse link 9 62,791,824 62,811,648 RGD:5509061
G Ffar1 free fatty acid receptor 1 JBrowse link 7 30,860,568 30,861,470 RGD:5509061
G Fkbp1b FK506 binding protein 1b JBrowse link 12 4,833,174 4,841,736 RGD:5509061
G Foxa1 forkhead box A1 JBrowse link 12 57,540,628 57,548,029 RGD:5509061
G Foxo1 forkhead box O1 JBrowse link 3 52,268,337 52,350,109 RGD:5509061
G Foxo4 forkhead box O4 JBrowse link X 101,254,261 101,260,873 RGD:5509061
G Gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 JBrowse link 8 84,832,282 84,835,482 RGD:5509061
G Gal galanin and GMAP prepropeptide JBrowse link 19 3,409,915 3,414,544 RGD:5509061
G Gck glucokinase JBrowse link 11 5,900,816 5,950,081 RGD:5509061
G Gem GTP binding protein (gene overexpressed in skeletal muscle) JBrowse link 4 11,704,447 11,714,993 RGD:5509061
G Ghr growth hormone receptor JBrowse link 15 3,317,755 3,583,352 RGD:5509061
G Gjd2 gap junction protein, delta 2 JBrowse link 2 114,009,601 114,014,378 RGD:5509061
G Glis3 GLIS family zinc finger 3 JBrowse link 19 28,258,851 28,680,265 RGD:5509061
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 5 139,423,150 139,427,800 RGD:5509061
G Gpr68 G protein-coupled receptor 68 JBrowse link 12 100,876,679 100,908,198 RGD:5509061
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano JBrowse link 6 113,067,428 113,077,244 RGD:5509061
G Hint2 histidine triad nucleotide binding protein 2 JBrowse link 4 43,654,227 43,656,445 RGD:5509061
G Hipk3 homeodomain interacting protein kinase 3 JBrowse link 2 104,426,481 104,494,489 RGD:5509061
G Hmga1 high mobility group AT-hook 1 JBrowse link 17 27,556,574 27,563,672 RGD:5509061
G Hnf1a HNF1 homeobox A JBrowse link 5 114,948,980 114,971,062 RGD:5509061
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:5509061
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:5509061
G Ins2 insulin II JBrowse link 7 142,678,656 142,679,726 RGD:5509061
G Insr insulin receptor JBrowse link 8 3,150,922 3,279,649 RGD:5509061
G Irs1 insulin receptor substrate 1 JBrowse link 1 82,233,105 82,291,439 RGD:5509061
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 JBrowse link 6 108,213,083 108,551,116 RGD:5509061
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 JBrowse link 7 46,097,123 46,100,952 RGD:5509061
G Kif5b kinesin family member 5B JBrowse link 18 6,201,005 6,241,524 RGD:5509061
G Kl klotho JBrowse link 5 150,952,607 150,993,817 RGD:5509061
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 3 107,278,858 107,284,082 RGD:5509061
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:5509061
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:5509061
G Lpin1 lipin 1 JBrowse link 12 16,535,669 16,653,903 RGD:5509061
G Lrp5 low density lipoprotein receptor-related protein 5 JBrowse link 19 3,584,825 3,686,585 RGD:5509061
G Madd MAP-kinase activating death domain JBrowse link 2 91,137,360 91,184,006 RGD:5509061
G Mafa v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) JBrowse link 15 75,745,501 75,748,321 RGD:5509061
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:5509061
G Met met proto-oncogene JBrowse link 6 17,463,349 17,573,980 RGD:5509061
G Mpc2 mitochondrial pyruvate carrier 2 JBrowse link 1 165,461,260 165,481,218 RGD:5509061
G Myrip myosin VIIA and Rab interacting protein JBrowse link 9 120,303,520 120,476,101 RGD:5509061
G Myt1 myelin transcription factor 1 JBrowse link 2 181,763,332 181,827,775 RGD:5509061
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 12 32,820,335 32,853,369 RGD:5509061
G Nkx2-2 NK2 homeobox 2 JBrowse link 2 147,176,485 147,195,434 RGD:5509061
G Nkx6-1 NK6 homeobox 1 JBrowse link 5 101,659,184 101,664,711 RGD:5509061
G Nnt nicotinamide nucleotide transhydrogenase JBrowse link 13 119,335,527 119,409,257 RGD:5509061
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 JBrowse link 7 70,351,946 70,366,746 RGD:5509061
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 16 29,579,281 29,663,127 RGD:5509061
G Pask PAS domain containing serine/threonine kinase JBrowse link 1 93,309,437 93,343,522 RGD:5509061
G Pbx1 pre B cell leukemia homeobox 1 JBrowse link 1 168,119,364 168,432,365 RGD:5509061
G Pcsk2 proprotein convertase subtilisin/kexin type 2 JBrowse link 2 143,546,133 143,816,284 RGD:5509061
G Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link 17 24,073,680 24,155,619 RGD:5509061
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 5 147,270,097 147,275,848 RGD:5509061
G Pfkm phosphofructokinase, muscle JBrowse link 15 98,092,589 98,132,447 RGD:5509061
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:5509061
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:5509061
G Prkaca protein kinase, cAMP dependent, catalytic, alpha JBrowse link 8 83,972,978 83,996,444 RGD:5509061
G Prkcd protein kinase C, delta JBrowse link 14 30,595,353 30,626,414 RGD:5509061
G Prlr prolactin receptor JBrowse link 15 10,177,238 10,349,190 RGD:5509061
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 JBrowse link 15 97,744,770 97,768,419 RGD:5509061
G Rarres2 retinoic acid receptor responder (tazarotene induced) 2 JBrowse link 6 48,569,696 48,572,845 RGD:5509061
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 15 6,708,349 6,800,401 RGD:5509061
G Rims2 regulating synaptic membrane exocytosis 2 JBrowse link 15 39,198,286 39,684,372 RGD:5509061
G Rnf213 ring finger protein 213 JBrowse link 11 119,389,950 119,487,418 RGD:5509061
G Rph3al rabphilin 3A-like (without C2 domains) JBrowse link 11 75,830,992 75,967,614 RGD:5509061
G Rps6 ribosomal protein S6 JBrowse link 4 86,854,099 86,857,367 RGD:5509061
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:5509061
G Samd4 sterile alpha motif domain containing 4 JBrowse link 14 46,882,965 47,105,817 RGD:5509061
G Selenot selenoprotein T JBrowse link 3 58,576,636 58,593,544 RGD:5509061
G Senp1 SUMO1/sentrin specific peptidase 1 JBrowse link 15 98,038,744 98,093,569 RGD:5509061
G Sertad1 SERTA domain containing 1 JBrowse link 7 27,486,953 27,490,316 RGD:5509061
G Sgms1 sphingomyelin synthase 1 JBrowse link 19 32,122,727 32,389,885 RGD:5509061
G Sgpp2 sphingosine-1-phosphate phosphotase 2 JBrowse link 1 78,309,549 78,420,289 RGD:5509061
G Sh2b1 SH2B adaptor protein 1 JBrowse link 7 126,466,993 126,476,650 RGD:5509061
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 JBrowse link 3 28,697,903 28,728,361 RGD:5509061
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 JBrowse link 11 69,942,286 69,948,216 RGD:5509061
G Slc30a8 solute carrier family 30 (zinc transporter), member 8 JBrowse link 15 52,295,553 52,335,798 RGD:5509061
G Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 JBrowse link 3 135,307,651 135,342,845 RGD:5509061
G Snap25 synaptosomal-associated protein 25 JBrowse link 2 136,713,439 136,782,428 RGD:5509061
G Sox4 SRY (sex determining region Y)-box 4 JBrowse link 13 28,948,919 28,953,699 RGD:5509061
G Sox9 SRY (sex determining region Y)-box 9 JBrowse link 11 112,782,210 112,787,757 RGD:5509061
G Speer6-ps1 spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1 JBrowse link 13 3,149,475 3,189,678 RGD:5509061
G Spop speckle-type BTB/POZ protein JBrowse link 11 95,414,083 95,493,410 RGD:5509061
G Sstr5 somatostatin receptor 5 JBrowse link 17 25,489,875 25,497,288 RGD:5509061
G Stat5a signal transducer and activator of transcription 5A JBrowse link 11 100,859,351 100,885,169 RGD:5509061
G Stat5b signal transducer and activator of transcription 5B JBrowse link 11 100,780,731 100,859,004 RGD:5509061
G Stxbp3 syntaxin binding protein 3 JBrowse link 3 108,793,180 108,840,502 RGD:5509061
G Sytl1 synaptotagmin-like 1 JBrowse link 4 133,253,090 133,263,087 RGD:5509061
G Sytl4 synaptotagmin-like 4 JBrowse link X 133,936,385 133,981,821 RGD:5509061
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box JBrowse link 19 55,741,797 55,933,659 RGD:5509061
G Tcirg1 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 JBrowse link 19 3,896,050 3,907,133 RGD:5509061
G Tfam transcription factor A, mitochondrial JBrowse link 10 71,225,468 71,238,328 RGD:5509061
G Tgfbi transforming growth factor, beta induced JBrowse link 13 56,609,586 56,639,359 RGD:5509061
G Trh thyrotropin releasing hormone JBrowse link 6 92,242,061 92,244,650 RGD:5509061
G Ucn3 urocortin 3 JBrowse link 13 3,940,688 3,945,349 RGD:5509061
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 5 36,966,104 36,988,982 RGD:5509061

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 13565
    homeostasis/metabolism phenotype 5625
      abnormal homeostasis 4883
        abnormal glucose homeostasis 1469
          abnormal insulin secretion 180
            decreased insulin secretion 134
Path 2
Term Annotations click to browse term
  mammalian phenotype 13565
    endocrine/exocrine gland phenotype 2532
      abnormal gland physiology 725
        abnormal pancreas physiology 328
          abnormal endocrine pancreas physiology 209
            abnormal pancreatic beta cell physiology 206
              abnormal insulin secretion 180
                decreased insulin secretion 134
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.