MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: increased systemic arterial blood pressure
Accession: MP:0002842
browse the term
Definition: increased tension of the blood within the systemic arteries
Synonyms: exact_synonym: high blood pressure
narrow_synonym: Increased blood pressure
xref: HP:0032263
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Apoe
apolipoprotein E
IMP
RGD
PMID:29166645
RGD:150520219
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Apoeem1Ejt
apolipoprotein E; TALEN induced mutant 1, Ejt
IMP
RGD
PMID:29166645
RGD:150520219
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Apoeem1Sage
apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
RGD
PMID:29166645
RGD:150520219
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Ddx52
DExD-box helicase 52
IAGP
DNA:polymorphism
RGD
PMID:17218081
RGD:1599269
NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266
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Ednrb
endothelin receptor type B
IDA
RGD
PMID:16179487
RGD:1581856
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Glp1r
glucagon-like peptide 1 receptor
IDA
RGD
PMID:12093887
RGD:625448
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
IDA
RGD
PMID:14551242
RGD:1298970
NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
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Npr1
natriuretic peptide receptor 1
IAGP
RGD
PMID:7629399
RGD:1357231
NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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Ren
renin
IAGP
RGD
PMID:8567976
RGD:61046
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Tnf
tumor necrosis factor
IAGP
RGD
PMID:9590569
RGD:1357163
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
IMP
RGD
PMID:23753405
RGD:13782272
NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
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Kcnj1em1Kasu
potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu
IMP
RGD
PMID:23753405
RGD:13782272
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Ncf2
neutrophil cytosolic factor 2
induces
IMP
compared to wild-type littermates
RGD
PMID:22326221 PMID:22326221
RGD:9587793 , RGD:9587793
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
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Ncf2em1Mcwi
neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi
induces
IMP
compared to wild-type littermates
RGD
PMID:22326221 PMID:22326221
RGD:9587793 , RGD:9587793
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Nox4
NADPH oxidase 4
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nox4em2Mcwi
NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
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Plekha7
pleckstrin homology domain containing A7
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775
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Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
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Sh2b3
SH2B adaptor protein 3
IMP
RGD
PMID:25776069
RGD:13442483
NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616
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Sh2b3em1Mcwi
SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
RGD
PMID:25776069
RGD:13442483
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Lepr
leptin receptor
IMP IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:27465994 PMID:30278832
RGD:12911217 , RGD:401960095
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Nppb
natriuretic peptide B
IMP
RGD
PMID:26063669
RGD:12910116
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nppbem2Mcwi
natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26063669
RGD:12910116
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Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005
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Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
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Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Rag1
recombination activating 1
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
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Rag1em1Mcwi
recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
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Rag1em2Mcwi
recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
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Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
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Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
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Tmem67
transmembrane protein 67
IAGP
RGD
PMID:11095650
RGD:1300514
NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334
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Tmem67wpk
transmembrane protein 67; wpk mutant
IAGP
RGD
PMID:11095650
RGD:1300514
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Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Npr1
natriuretic peptide receptor 1
IAGP
RGD
PMID:12511524
RGD:628585
NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
RGD
PMID:29906243
RGD:38596340
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
RGD
PMID:29906243
RGD:38596340
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Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
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Add1
adducin 1
IAGP
RGD
PMID:15474463
RGD:1302895
NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
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Adora2b
adenosine A2B receptor
IMP
RGD
PMID:26385692
RGD:11533328
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Adora2bem2Mcwi
adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26385692
RGD:11533328
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Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005
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Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
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Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
IAGP
RGD
PMID:7981756
RGD:69709
NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
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Ednra
endothelin receptor type A
IDA
RGD
PMID:16157796
RGD:1581830
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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Egln1
egl-9 family hypoxia-inducible factor 1
IAGP
DNA:duplication
RGD
PMID:20231529
RGD:11251783
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
IAGP
DNA:deletion:exon (rat)
RGD
PMID:16368876
RGD:1581602
NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
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Kcnq1dfk
potassium voltage-gated channel subfamily Q member 1;deafness Kyoto
IAGP
RGD
PMID:16368876
RGD:1581602
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Lepr
leptin receptor
treatment onset
IAGP IMP
compared to treated compared to SS/JrHsdMcwi
RGD
PMID:23154293 PMID:33568522 PMID:27465994
RGD:13432147 , RGD:401965412 , RGD:12911217
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:27465994
RGD:12911217
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Leprfa
leptin receptor; fa mutant
IAGP
RGD
PMID:23154293
RGD:13432147
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Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,340,674...158,367,581
Ensembl chr 5:158,340,490...158,367,620
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Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
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Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
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Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005
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Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
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Astn1
astrotactin 1
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:70,537,423...70,855,440
Ensembl chr13:70,537,703...70,855,440
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Brinp2
BMP/retinoic acid inducible neural specific 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810
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Btg2
BTG anti-proliferation factor 2
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Cd247
Cd247 molecule
severity
IMP
RGD
PMID:24343121
RGD:13442481
NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
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Cd247em1Mcwi
Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
severity
IMP
RGD
PMID:24343121
RGD:13442481
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Chi3l1
chitinase 3 like 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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Chit1
chitinase 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:45,565,841...45,613,593
Ensembl chr13:45,593,845...45,613,592
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Cop1
COP1, E3 ubiquitin ligase
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890
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Etnk2
ethanolamine kinase 2
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037
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Fmod
fibromodulin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
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Gpr37l1
G protein-coupled receptor 37-like 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,598,574...46,605,421
Ensembl chr13:46,598,578...46,605,421
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Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IMP
RGD
PMID:26077568
RGD:13800514
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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Hsd11b2em1Jmul
hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
IMP
RGD
PMID:26077568
RGD:13800514
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Ipo9
importin 9
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,810,460...46,862,694
Ensembl chr13:46,813,171...46,862,673
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Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
IMP
RGD
PMID:23753405
RGD:13782272
NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
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Kcnj1em1Kasu
potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu
IMP
RGD
PMID:23753405
RGD:13782272
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Lgr6
leucine-rich repeat-containing G protein-coupled receptor 6
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,424,382...46,544,074
Ensembl chr13:46,424,383...46,543,945
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Mgat5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513
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Mybph
myosin binding protein H
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Ncf2
neutrophil cytosolic factor 2
ameliorates
IMP
compared to wild-type littermates
RGD
PMID:22326221
RGD:9587793
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
G
Ncf2em1Mcwi
neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi
ameliorates
IMP
compared to wild-type littermates
RGD
PMID:22326221
RGD:9587793
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Nckap5
NCK-associated protein 5
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:37,369,948...38,283,257
Ensembl chr13:37,370,792...38,283,268
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Nox4
NADPH oxidase 4
severity
IMP
RGD
PMID:26644237
RGD:11085830
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Optc
opticin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237
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Pappa2
pappalysin 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:70,873,918...71,147,874
Ensembl chr13:70,876,794...71,147,779
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Plekha6
pleckstrin homology domain containing A6
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:44,614,740...44,754,951
Ensembl chr13:44,615,011...44,754,673
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Plekha7
pleckstrin homology domain containing A7
ameliorates
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775
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Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
ameliorates
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
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Prelp
proline and arginine rich end leucine rich repeat protein
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270
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Psme2-ps1
proteasome activator subunit 2, pseudogene 1
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:38,189,375...38,190,347
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Ptprv
protein tyrosine phosphatase, receptor type, V
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,548,125...46,569,148
Ensembl chr13:46,548,128...46,568,329
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Ren
renin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Resp18
regulated endocrine-specific protein 18
IMP
RGD
PMID:29570433
RGD:14348960
NCBI chr 9:76,765,179...76,771,824
Ensembl chr 9:76,764,590...76,778,722
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Resp18em2Mcwi
regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:29570433
RGD:14348960
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Rnpep
arginyl aminopeptidase
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
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Sox13
SRY-box transcription factor 13
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:44,831,097...44,875,522
Ensembl chr13:44,831,085...44,875,762
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Syt2
synaptotagmin 2
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859
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Tmem163
transmembrane protein 163
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:38,967,913...39,141,664
Ensembl chr13:38,968,101...39,141,452
G
Tnr
tenascin R
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:71,751,714...72,172,731
Ensembl chr13:72,091,585...72,167,641
G
tuba1c-ps1
tubulin, alpha 1C, pseudogene 1
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:38,507,496...38,508,836
Ensembl chr13:38,507,401...38,508,943 Ensembl chr13:38,507,401...38,508,943
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all