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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal cocaine consumption
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Accession:MP:0002556 term browser browse the term
Definition:aberrant behavioral-related or physiological-related intake of cocaine into the body
Synonyms:exact_synonym: cocaine consumption
 alt_id: MP:0002569



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abnormal acquisiton of operant behavior for a cocaine reinforcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit IMP RGD PMID:32841724 RGD:150530292 NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrna5em20(D398N)Pas cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 20,Pas IMP RGD PMID:32841724 RGD:150530292
G Slc6a4 solute carrier family 6 member 4 IMP compared to wild type littermate RGD PMID:18581099 RGD:4889490 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slc6a4m1Hubr solute carrier family 6 member 4; ZFN induced mutant1, Hubr IMP compared to wild type littermate RGD PMID:18581099 RGD:4889490
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 IMP RGD PMID:26988269 PMID:24555056 RGD:126848803, RGD:126848805 NCBI chr 2:140,457,841...140,629,556
Ensembl chr 2:138,308,084...138,476,768
JBrowse link
G Trpc4Tn(sb)Tngen transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen IMP RGD PMID:24555056 PMID:26988269 RGD:126848805, RGD:126848803
abnormal cocaine self-administration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm2 glutamate metabotropic receptor 2 IMP KO compared to wild-type rats RGD PMID:28700935 RGD:38501064 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 RGD:38501064
G Slc6a4 solute carrier family 6 member 4 IMP RGD PMID:30144237 RGD:401938631 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slc6a4m1Hubr solute carrier family 6 member 4; ZFN induced mutant1, Hubr IMP RGD PMID:30144237 RGD:401938631
abnormal cue-induced reinstatement of an extinguished operant behavior for a cocaine reinforcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 IMP knock-out compared to wild-type rats RGD PMID:28387990 RGD:13503340 NCBI chr19:63,258,251...64,296,122
Ensembl chr19:46,349,430...47,387,459
JBrowse link
G Cdh13em1Mcwi cadherin 13; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP knock-out compared to wild-type rats RGD PMID:28387990 RGD:13503340
G Grm2 glutamate metabotropic receptor 2 IMP knock-out compared to wild-type rats
knockout compared to wild type
RGD PMID:30283001 PMID:28700935 RGD:38501063, RGD:38501064 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 PMID:30283001 RGD:38501064, RGD:38501063
abnormal drug-induced reinstatement of an extinguished operant behavior for a drug reinforcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 IMP RGD PMID:37190555 RGD:596933068 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ameliorates IMP RGD PMID:23671067 RGD:401938637 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
abnormal extinction of cocaine self-administration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm2 glutamate metabotropic receptor 2 IMP knockout compared to wild type RGD PMID:28700935 RGD:38501064 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm2em1 glutamate metabotropic receptor 2; endonuclease induced mutant 1 IMP KO compared to wild-type rats RGD PMID:28700935 RGD:38501064
abnormal reinstatement of an extinguished operant behavior for a cocaine reinforcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit IMP RGD PMID:32841724 RGD:150530292 NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrna5em18Pas cholinergic receptor, nicotinic, alpha 5 (neuronal); ZFN induced mutant 18,Pas IMP RGD PMID:32841724 RGD:150530292
cocaine preference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor severity IMP RGD PMID:23583595 RGD:38501054 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP RGD PMID:23583595 RGD:38501054

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5421
    behavior/neurological phenotype 614
      abnormal behavior 613
        abnormal behavioral response to xenobiotic 141
          abnormal cocaine consumption 24
            abnormal cocaine self-administration + 24
paths to the root