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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal type III hypersensitivity reaction
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Accession:MP:0002533 term browser browse the term
Definition:anomaly in the tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
Comment:Examples: Autoimmune diseases: systemic lupus erythmatosus (SLE), rheumatoid arthritis, sjogren syndrome, scleroderma and glomerulonephritis.
Synonyms:exact_synonym: immune complex mediated hypersensitivity



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increased susceptibility to type III hypersensitivity reaction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule IMP RGD PMID:28212662 RGD:13792592 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd59em1Ask CD59 molecule; CRISPR/Cas9 induced mutant1, Ask IMP RGD PMID:28212662 RGD:13792592

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5292
    immune system phenotype 485
      abnormal immune system physiology 373
        abnormal hypersensitivity reaction 4
          abnormal type III hypersensitivity reaction 3
            decreased susceptibility to type III hypersensitivity reaction 0
            increased susceptibility to type III hypersensitivity reaction 3
Path 2
Term Annotations click to browse term
  mammalian phenotype 5292
    immune system phenotype 485
      abnormal immune system physiology 373
        abnormal inflammatory response 227
          abnormal acute inflammation 5
            abnormal type III hypersensitivity reaction 3
              decreased susceptibility to type III hypersensitivity reaction 0
              increased susceptibility to type III hypersensitivity reaction 3
paths to the root