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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal B cell physiology
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Accession:MP:0002459 term browser browse the term
Definition:any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
Synonyms:exact_synonym: B cell dysfunction;   B lymphocyte dysfunction;   B lymphocyte functional anomalies



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Path 1
Term Annotations click to browse term
  mammalian phenotype 8
    immune system phenotype 0
      abnormal immune system physiology 0
        abnormal cell-mediated immunity 0
          abnormal professional antigen presenting cell physiology 0
            abnormal B cell physiology 0
              abnormal B cell activation + 0
              abnormal B cell apoptosis + 0
              abnormal B lymphocyte antigen presentation 0
              abnormal class switch recombination 0
              abnormal follicular B cell physiology 0
              abnormal germinal center B cell physiology 0
              abnormal immunoglobulin level + 0
              abnormal marginal zone B cell physiology 0
              abnormal memory B cell physiology 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 8
    immune system phenotype 0
      abnormal immune system physiology 0
        abnormal immune cell physiology 0
          abnormal leukocyte physiology 0
            abnormal lymphocyte physiology 0
              abnormal B cell physiology 0
                abnormal B cell activation + 0
                abnormal B cell apoptosis + 0
                abnormal B lymphocyte antigen presentation 0
                abnormal class switch recombination 0
                abnormal follicular B cell physiology 0
                abnormal germinal center B cell physiology 0
                abnormal immunoglobulin level + 0
                abnormal marginal zone B cell physiology 0
                abnormal memory B cell physiology 0
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