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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal susceptibility to autoimmune disorder
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Accession:MP:0002425 term browser browse the term
Definition:a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides
Synonyms:exact_synonym: abnormal autoimmune disorder susceptibility;   abnormal resistance to autoimmune disorder;   altered susceptibility to autoimmune disorder;   autoimmune disorders



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decreased susceptibility to autoimmune diabetes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnar1 interferon alpha and beta receptor subunit 1 IMP RGD PMID:27999109 RGD:12910492 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 IMP RGD PMID:27999109 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 IMP RGD PMID:27999109 RGD:12910492
decreased susceptibility to experimental autoimmune myasthenia gravis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6 complement C6 IAGP RGD PMID:17034580 RGD:1600670 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link
increased susceptibility to induced arthritis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncf1 neutrophil cytosolic factor 1 IAGP RGD PMID:12461526 RGD:628543 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5292
    immune system phenotype 485
      abnormal immune system physiology 373
        abnormal immune tolerance 117
          abnormal self tolerance 117
            autoimmune response 117
              abnormal susceptibility to autoimmune disorder 106
                decreased susceptibility to autoimmune disorder + 62
                increased susceptibility to autoimmune disorder + 47
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