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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal double-negative T cell morphology
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Accession:MP:0002407 term browser browse the term
Definition:any structural anomaly of the subset of T cells found in the thymus that express neither CD4 nor CD8
Comment:These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes.
Synonyms:exact_synonym: CD4-CD8- T cell abnormalities;   double-negative T cell abnormalities


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increased double-negative T cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
Q Neudeg2 Neurodegradation QTL 2 IAGP RGD PMID:14586010 RGD:1358788 NCBI chr 5:24,838,710...44,045,280 JBrowse link
Q Neuinf1 Neuroinflammation QTL 1 IAGP RGD PMID:14586010 RGD:1358788 NCBI chr 5:154,828,214...166,875,058 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system development 19
          abnormal leukopoiesis 16
            abnormal lymphopoiesis 16
              abnormal T cell differentiation 16
                abnormal double-negative T cell morphology 2
                  decreased double-negative T cell number + 0
                  increased double-negative T cell number + 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    hematopoietic system phenotype 246
      abnormal hematopoietic system morphology/development 226
        abnormal hematopoietic cell morphology 182
          abnormal blood cell morphology 95
            abnormal hemopoiesis 16
              abnormal definitive hematopoiesis 16
                abnormal leukopoiesis 16
                  abnormal lymphopoiesis 16
                    abnormal T cell differentiation 16
                      abnormal double-negative T cell morphology 2
                        decreased double-negative T cell number + 0
                        increased double-negative T cell number + 2
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