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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal spleen white pulp morphology
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Accession:MP:0002357 term browser browse the term
Definition:any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
Comment:Note that there is no consensus in the literature about which compartments constitute the white pulp or the ramifications of the microvasculature. In addition, notable differences exist between humans and rodents. In this ontology, the marginal sinus and marginal zone have been included as part of the white pulp.
Synonyms:exact_synonym: abnormal splenic white pulp morphology


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abnormal spleen B cell follicle morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednrb endothelin receptor type B IAGP RGD PMID:22975636 RGD:7207471 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Ednrbsl endothelin receptor type B, spotting lethal IAGP RGD PMID:22975636 RGD:7207471
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    hematopoietic system phenotype 246
      abnormal hematopoietic system morphology/development 226
        abnormal spleen morphology 33
          abnormal spleen white pulp morphology 3
            abnormal metallophilic macrophage morphology 0
            abnormal spleen B cell follicle morphology + 3
            abnormal spleen central arteriole morphology 0
            abnormal spleen marginal sinus morphology 0
            abnormal spleen marginal zone morphology + 0
            abnormal spleen periarteriolar lymphoid sheath morphology 0
            absent spleen white pulp 0
            decreased spleen white pulp amount 0
            increased spleen white pulp amount 0
            intermingled spleen red and white pulp 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5417
    immune system phenotype 498
      abnormal immune system morphology 190
        abnormal immune system organ morphology 73
          abnormal spleen morphology 33
            abnormal spleen white pulp morphology 3
              abnormal metallophilic macrophage morphology 0
              abnormal spleen B cell follicle morphology + 3
              abnormal spleen central arteriole morphology 0
              abnormal spleen marginal sinus morphology 0
              abnormal spleen marginal zone morphology + 0
              abnormal spleen periarteriolar lymphoid sheath morphology 0
              absent spleen white pulp 0
              decreased spleen white pulp amount 0
              increased spleen white pulp amount 0
              intermingled spleen red and white pulp 0
paths to the root