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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal long-term potentiation
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Accession:MP:0002207 term browser browse the term
Definition:alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells
Synonyms:exact_synonym: abnormal LTP;   central nervous system: LTP anomalies;   long term potentiation abnormalities
 narrow_synonym: abnormal LTP: CA1 region;   abnormal LTP: CA3 region
 alt_id: MP:0001472;   MP:0001896;   MP:0001897;   MP:0002154
 xref: MGI:2173614


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enhanced long-term potentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcz protein kinase C, zeta IDA normal enhancement of long-term potentiation RGD PMID:15728837 RGD:1642696 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
reduced long-term potentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:11112797 RGD:2292520 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G KitWs KIT proto-oncogene receptor tyrosine kinase; mutant 1 IMP RGD PMID:11112797 RGD:2292520
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta IMP RGD PMID:33479380 RGD:150519900 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942 		JBrowse link
G Prkar1bem2Tua protein kinase cAMP-dependent type I regulatory subunit beta; CRISPR/Cas9 induced mutant 2, Tua IMP RGD PMID:33479380 RGD:150519900
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5420
    nervous system phenotype 376
      abnormal nervous system physiology 218
        abnormal synaptic physiology 47
          abnormal synaptic transmission 46
            abnormal CNS synaptic transmission 42
              abnormal long-term potentiation 7
                enhanced long-term potentiation 1
                reduced long-term potentiation 6
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