MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: abnormal glucose homeostasis
Accession: MP:0002078
browse the term
Definition: anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues
Synonyms: exact_synonym: metabolism: abnormal glucose homeostasis
narrow_synonym: abnormal glucose metabolism
xref: MGI:2173579
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Apoa4
apolipoprotein A4
induces
IMP
compared to wild type
RGD
PMID:31303888
RGD:150429948
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoa4em1Bcgen
apolipoprotein A4; TALEN induced mutant 1, Bcgn
induces
IMP
compared to wild type
RGD
PMID:31303888
RGD:150429948
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Gck
glucokinase
IDA
RGD
PMID:10512368
RGD:2301945
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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Gla
galactosidase, alpha
IMP
compared to Wild type males
RGD
PMID:29979634
RGD:401976416
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
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Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
IMP
compared to Wild type males
RGD
PMID:29979634
RGD:401976416
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Glp1r
glucagon-like peptide 1 receptor
NOT
IDA
RGD
PMID:12093887
RGD:625448
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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Gja8
gap junction protein, alpha 8
IAGP
RGD
PMID:27871290
RGD:150429989
NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
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Gja8m1Cub
gap junction protein, alpha 8; mutant 1 Cub
IAGP
RGD
PMID:27871290
RGD:150429989
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Tbc1d1
TBC1 domain family member 1
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
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Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
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Abcc8
ATP binding cassette subfamily C member 8
IAGP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IAGP
compared to wild type
RGD
PMID:30616503
RGD:150573710
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Cfb
complement factor B
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Cfbem1Tja
complement factor B, ZFN induced mutant 1, Tja
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
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Gja8
gap junction protein, alpha 8
induces
IAGP
RGD
PMID:27871290
RGD:150429989
NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
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Gja8m1Cub
gap junction protein, alpha 8; mutant 1 Cub
induces
IAGP
RGD
PMID:27871290
RGD:150429989
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Tbc1d1
TBC1 domain family member 1
induces
IMP
compared to Wild type and heterozygous
RGD
PMID:28177704
RGD:150521607
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
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Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
compared to Wild type and heterozygous
RGD
PMID:28177704
RGD:150521607
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Abcc8
ATP binding cassette subfamily C member 8
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
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Tbc1d1
TBC1 domain family member 1
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
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Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
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Wfs1
wolframin ER transmembrane glycoprotein
induces
IMP
RGD
PMID:29976929
RGD:150519890
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
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Wfs1em1Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
induces
IMP
RGD
PMID:29976929
RGD:150519890
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
IAGP
RGD
PMID:25505293
RGD:9835029
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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Wfs1
wolframin ER transmembrane glycoprotein
onset
IMP
RGD
PMID:28860598
RGD:149735331
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
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Wfs1em1Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
onset
IMP
RGD
PMID:28860598
RGD:149735331
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Abcc8
ATP binding cassette subfamily C member 8
IAGP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IAGP
compared to wild type
RGD
PMID:30616503
RGD:150573710
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Ldlr
low density lipoprotein receptor
IMP
RGD
PMID:28469073
RGD:12910100
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Ldlrem1Sage
low density lipoprotein receptor; ZFN induced mutant 1, Sage
IMP
RGD
PMID:28469073
RGD:12910100
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Lepr
leptin receptor
IMP
compared to SS/JrHsdMcwi
RGD
PMID:27225180 PMID:27465994
RGD:12910507 , RGD:12911217
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi
RGD
PMID:27465994
RGD:12911217
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Leprem3
leptin receptor; TALEN induced mutant 3
IMP
RGD
PMID:27225180
RGD:12910507
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Pparg
peroxisome proliferator-activated receptor gamma
IAGP
compared to wild type rats
RGD
PMID:27381370
RGD:127285618
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppargm1Kyo
peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo
IAGP
compared to wild type rats
RGD
PMID:27381370
RGD:127285618
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Tbc1d4
TBC1 domain family, member 4
IMP
RGD
PMID:32053588 PMID:31034517
RGD:38596323 , RGD:38596332
NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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Tbc1d4em1
TBC1 domain family, member 4; CRISPR/Cas9 system induced mutant 1,
IMP
RGD
PMID:32053588 PMID:31034517
RGD:38596323 , RGD:38596332
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Wfs1
wolframin ER transmembrane glycoprotein
onset
IMP
RGD
PMID:28860598
RGD:149735331
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
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Wfs1em1Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
onset
IMP
RGD
PMID:28860598
RGD:149735331
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Wfs1em2Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 2
onset
IMP
RGD
PMID:28860598
RGD:149735331
G
Wfs1em3Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 3
onset
IMP
RGD
PMID:28860598
RGD:149735331
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Dpp4
dipeptidylpeptidase 4
IAGP
compared to DA/Ztm
RGD
PMID:19327106
RGD:41408336
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dpp4DPPIV
dipeptidylpeptidase 4; DPPIV mutant
IAGP
compared to DA/Ztm
RGD
PMID:19327106
RGD:41408336
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Zbtb16
zinc finger and BTB domain containing 16
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
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Dpp4
dipeptidylpeptidase 4
IAGP
compared to DA/Ztm
RGD
PMID:19327106
RGD:41408336
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dpp4DPPIV
dipeptidylpeptidase 4; DPPIV mutant
IAGP
compared to DA/Ztm
RGD
PMID:19327106
RGD:41408336
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp2j4em1Sage
cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage
induces
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
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Insr
insulin receptor
induced
IMP
RGD
PMID:19017805
RGD:2314405
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:28124283
RGD:13703118
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
RGD
PMID:28124283
RGD:13703118
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Lep
leptin
IMP
RGD
PMID:22948215
RGD:12904911
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepem1Sage
leptin; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:22948215
RGD:12904911
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Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530 PMID:10901178 PMID:28746409
RGD:401960103 , RGD:401965414 , RGD:401965413
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Tbc1d1
TBC1 domain family member 1
induces
IMP
compared to Wild type
RGD
PMID:28808062
RGD:150521563
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
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Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
compared to Wild type
RGD
PMID:28808062
RGD:150521563
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Trpc6
transient receptor potential cation channel, subfamily C, member 6
induces
IMP
compared to vehicle-treated wild type and control
RGD
PMID:29923767
RGD:149735534
NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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Trpc6em1Mcwi
transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin
induces
IMP
compared to vehicle-treated wild type and control
RGD
PMID:29923767
RGD:149735534
G
Wfs1
wolframin ER transmembrane glycoprotein
onset
IMP
RGD
PMID:28860598
RGD:149735331
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
G
Wfs1em1Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
onset
IMP
RGD
PMID:28860598
RGD:149735331
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Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
IMP
RGD
PMID:25934999
RGD:11085488
NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421
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Bscl2m1Kyo
BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo
IMP
RGD
PMID:25934999
RGD:11085488
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
G
Cyp2j4em1Sage
cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage
IMP
compared to wild type
RGD
PMID:29656108
RGD:150520032
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Gja8
gap junction protein, alpha 8
IAGP
RGD
PMID:27871290
RGD:150429989
NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456
G
Gja8m1Cub
gap junction protein, alpha 8; mutant 1 Cub
IAGP
RGD
PMID:27871290
RGD:150429989
G
Insr
insulin receptor
induced
IMP
RGD
PMID:19017805
RGD:2314405
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
G
Lepr
leptin receptor
IMP IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:27465994 PMID:28746409
RGD:12911217 , RGD:401965413
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:27465994
RGD:12911217
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Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
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Tbc1d1
TBC1 domain family member 1
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
G
Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
compared to Wild type
RGD
PMID:28177704
RGD:150521607
G
Cd36
CD36 molecule
IMP
compared to SHR/OlaIpcv
RGD
PMID:14640889
RGD:1600636
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
G
Glp1r
glucagon-like peptide 1 receptor
IDA
RGD
PMID:12093887
RGD:625448
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
G
Lrrk2
leucine-rich repeat kinase 2
IMP
RGD
PMID:23799078
RGD:13462048
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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Abcc8
ATP binding cassette subfamily C member 8
induces
IMP
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
G
Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
induces
IMP
RGD
PMID:30616503
RGD:150573710
G
Cfb
complement factor B
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
G
Cfbem1Tja
complement factor B, ZFN induced mutant 1, Tja
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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Hsd11b2em1Jmul
hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
G
Mir222
microRNA 222
treatment
IMP
associated with polycystic ovary syndrome;
RGD
PMID:33230470
RGD:151893462
NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006
G
Zbtb16
zinc finger and BTB domain containing 16
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
G
Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
G
Abcc8
ATP binding cassette subfamily C member 8
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
G
Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
G
Abcc8
ATP binding cassette subfamily C member 8
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
G
Abcc8em1Cgen
ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen
IMP
compared to wild type
RGD
PMID:30616503
RGD:150573710
G
Tbc1d1
TBC1 domain family member 1
induces
IMP
RGD
PMID:28808062
RGD:150521563
NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
G
Tbc1d1Tn(sb)1Fkh
TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh
induces
IMP
RGD
PMID:28808062
RGD:150521563
G
Ctns
cystinosin, lysosomal cystine transporter
IMP
RGD
PMID:35695380
RGD:155630629
NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
G
Gla
galactosidase, alpha
onset
IMP
compared to Wild type males
RGD
PMID:29979634
RGD:401976416
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
G
Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to Wild type males
RGD
PMID:29979634
RGD:401976416
G
Ptpn22
protein tyrosine phosphatase, non-receptor type 22
IAGP
RGD
PMID:25505293
RGD:9835029
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
G
Wfs1
wolframin ER transmembrane glycoprotein
onset
IMP
RGD
PMID:28860598
RGD:149735331
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
G
Wfs1em1Ptsn
wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
onset
IMP
RGD
PMID:28860598
RGD:149735331
G
Lepr
leptin receptor
IMP
RGD
PMID:27465994
RGD:12911217
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:27465994
RGD:12911217
G
Pparg
peroxisome proliferator-activated receptor gamma
induces
IAGP
compared to wild type rats
RGD
PMID:27381370
RGD:127285618
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargm1Kyo
peroxisome proliferator-activated receptor gamma; ENU induced mutant 1, Kyo
induces
IAGP
compared to wild type rats
RGD
PMID:27381370
RGD:127285618
G
Tbc1d4
TBC1 domain family, member 4
IMP
RGD
PMID:32053588 PMID:31034517
RGD:38596323 , RGD:38596332
NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
G
Tbc1d4em1
TBC1 domain family, member 4; CRISPR/Cas9 system induced mutant 1,
IMP
RGD
PMID:32053588 PMID:31034517
RGD:38596323 , RGD:38596332
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