Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:seizures
go back to main search page
Accession:MP:0002064 term browser browse the term
Definition:sudden and often acute manifestation of epileptic attack, sometimes convulsive
Synonyms:exact_synonym: Seizure
 broad_synonym: epilepsy;   neurological/behavioral: seizures/epilepsy;   neurological/behavioural: seizures/epilepsy;   seizures/epilepsy
 alt_id: MP:0000946;   MP:0001493
 xref: EFO:0000474;   HP:0001250;   MGI:2173569


show annotations for term's descendants           Sort by:
seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2d calcium/calmodulin-dependent protein kinase II delta IAGP DNA:SNP:intron:g.24024428G>T RGD PMID:20638246 RGD:6907065 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276 		JBrowse link
G Plp1 proteolipid protein 1 IAGP RGD PMID:2479544 RGD:1358781 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:104,975,780...104,993,314 		JBrowse link
G Plp1md proteolipid protein 1; Myelin-deficient IAGP RGD PMID:2479544 RGD:1358781
abnormal spike wave discharge term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml1 EMAP like 1 IAGP RGD PMID:32179177 RGD:407985868 NCBI chr 6:133,048,271...133,221,642
Ensembl chr 6:133,048,427...133,221,642 		JBrowse link
G Eml1tish EMAP like 1, tish mutant IAGP RGD PMID:32179177 RGD:407985868
G Fmr1 fragile X messenger ribonucleoprotein 1 IMP compared to wild type controls RGD PMID:38107412 RGD:401976423 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675 		JBrowse link
G Fmr1em2Mcwi FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin IMP compared to wild type controls RGD PMID:38107412 RGD:401976423
G Gad1 glutamate decarboxylase 1 onset IMP RGD PMID:37830095 RGD:405855846 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759 		JBrowse link
G Gad1em15Yyan glutamate decarboxylase 1; CRISPR/Cas9 induced mutant 15, Yyan onset IMP RGD PMID:37830095 RGD:405855846
audiogenic seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgi1 leucine-rich, glioma inactivated 1 IMP RGD PMID:30813600 RGD:14995940 NCBI chr 1:245,455,691...245,497,036
Ensembl chr 1:245,455,599...245,499,095 		JBrowse link
G Lgi1m1Kyo leucine-rich, glioma inactivated 1; ENU induced mutant1, Kyo IMP RGD PMID:30813600 RGD:14995940
G Lig1 DNA ligase 1 IMP RGD PMID:30813600 RGD:14995940 NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:83,219,545...83,281,708 		JBrowse link
G Wwox WW domain-containing oxidoreductase IAGP DNA:deletion:cds:exon 9, 13bp nucleotides 1190-1202 RGD PMID:19500159 RGD:150429979 NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:19500159 RGD:150429979
clonic seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 induces IMP RGD PMID:30408474 RGD:26923909 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806 		JBrowse link
G Hcn1em1Kyo hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; TALEN induced mutant 1, Kyo induces IMP RGD PMID:30408474 RGD:26923909
G Myo5a myosin VA IAGP DNA:rearrangement, deletion:exon:141-bp deletion position 1442-1582 RGD PMID:17185506 RGD:1600835 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:84,692,910...84,856,265 		JBrowse link
convulsive seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml1 EMAP like 1 IAGP RGD PMID:9236234 RGD:597538480 NCBI chr 6:133,048,271...133,221,642
Ensembl chr 6:133,048,427...133,221,642 		JBrowse link
G Eml1tish EMAP like 1, tish mutant IAGP RGD PMID:9236234 RGD:597538480
G Kcna1 potassium voltage-gated channel subfamily A member 1 IAGP RGD PMID:22206926 RGD:10047237 NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044 		JBrowse link
G Kcna1Adms potassium voltage-gated channel subfamily A member 1;autosomal dominant myokymia and seizures IAGP RGD PMID:22206926 RGD:10047237
decreased spike-wave discharge type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A IAGP RGD PMID:17196942 RGD:1598976 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna1agry calcium voltage-gated channel subunit alpha1 A; groggy mutant IAGP RGD PMID:17196942 RGD:1598976
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 treatment IMP compared to untreated RGD PMID:30408474 RGD:26923909 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806 		JBrowse link
G Hcn1em1Kyo hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; TALEN induced mutant 1, Kyo treatment IMP compared to untreated RGD PMID:30408474 RGD:26923909
environmentally induced seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cntnap2 contactin associated protein 2 IMP RGD PMID:28364455 RGD:12880397 NCBI chr 4:75,109,358...77,366,258
Ensembl chr 4:75,109,858...77,366,258 		JBrowse link
G Cntnap2em1Sage contactin associated protein-like 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:28364455 RGD:12880397
G Kcna1 potassium voltage-gated channel subfamily A member 1 IAGP RGD PMID:22206926 RGD:10047237 NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:161,147,418...161,160,044 		JBrowse link
G Kcna1Adms potassium voltage-gated channel subfamily A member 1;autosomal dominant myokymia and seizures IAGP RGD PMID:22206926 RGD:10047237
increased kindling response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1e calcium voltage-gated channel subunit alpha1 E IAGP RGD PMID:20638246 RGD:6907065 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a IMP DNA:mutation:cds:p.L174Q(rat) RGD PMID:27265781 RGD:12792961 NCBI chr 2:186,430,363...186,446,161
Ensembl chr 2:186,430,345...186,448,065 		JBrowse link
G Sv2am1Kyo synaptic vesicle glycoprotein 2a; ENU induced mutant 1, Kyo, IMP RGD PMID:27265781 RGD:12792961
increased spike-wave discharge type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 onset IMP RGD PMID:30408474 RGD:26923909 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806 		JBrowse link
G Hcn1em1Kyo hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; TALEN induced mutant 1, Kyo onset IMP RGD PMID:30408474 RGD:26923909
increased susceptibility to induction of seizure by inducing agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgi1 leucine-rich, glioma inactivated 1 IMP DNA:missense mutation:cds:p.L385R (c.1154T>G) RGD PMID:22589250 RGD:12792971 NCBI chr 1:245,455,691...245,497,036
Ensembl chr 1:245,455,599...245,499,095 		JBrowse link
G Lgi1m1Kyo leucine-rich, glioma inactivated 1; ENU induced mutant1, Kyo IMP DNA:missense mutation:cds:p.L385R (c.1154T>G) RGD PMID:22589250 RGD:12792971
G Scn1a sodium voltage-gated channel alpha subunit 1 IMP RGD PMID:20410126 RGD:12792282 NCBI chr 3:71,360,840...71,479,870
Ensembl chr 3:71,360,841...71,479,791 		JBrowse link
G Scn1am1Kyo sodium voltage-gated channel alpha subunit 1; ENU induced mutant1, Kyo IMP RGD PMID:20410126 RGD:12792282
G Scn1am2Kyo sodium voltage-gated channel alpha subunit 1; ENU induced mutant2, Kyo IMP RGD PMID:20410126 RGD:12792282
increased susceptibility to pharmacologically induced seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sv2a synaptic vesicle glycoprotein 2a IMP DNA:mutation:cds:p.L174Q(rat) RGD PMID:27265781 RGD:12792961 NCBI chr 2:186,430,363...186,446,161
Ensembl chr 2:186,430,345...186,448,065 		JBrowse link
G Sv2am1Kyo synaptic vesicle glycoprotein 2a; ENU induced mutant 1, Kyo, IMP RGD PMID:27265781 RGD:12792961
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    behavior/neurological phenotype 622
      abnormal behavior 621
        seizures 58
          abnormal seizure response to inducing agent + 27
          convulsive seizures + 21
          febrile seizures 0
          focal seizures 0
          nonconvulsive seizures + 22
          sporadic seizures 0
paths to the root