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Term:abnormal T cell activation
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Accession:MP:0001828 term browser browse the term
Definition:anomaly in the process of producing effector T cells from naive T cells
Comment:This process requires recognition of a foreign peptide fragment bound to self-MHC and the simultaneous delivery of a co-stimulatory signal by an antigen presenting cell; it results in the clonal expansion of naive T cells and their differentiation into armed effector cells.

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increased T cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
Q Ean2 Experimental allergic neuritis QTL 2 JBrowse link 4 84,475,257 97,479,149 RGD:2306769
Q Ean4 Experimental allergic neuritis QTL 4 JBrowse link 10 86,977,861 97,308,569 RGD:2306769
Q Ean5 Experimental allergic neuritis QTL 5 JBrowse link 10 75,045,391 97,308,358 RGD:2306769

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  mammalian phenotype 4934
    immune system phenotype 413
      abnormal immune system physiology 338
        abnormal immune cell physiology 33
          abnormal leukocyte physiology 33
            abnormal lymphocyte physiology 29
              abnormal T cell physiology 3
                abnormal T cell activation 3
                  abnormal T cell proliferation + 3
                  abnormal thymocyte activation 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.