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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:hyperactivity
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Accession:MP:0001399 term browser browse the term
Definition:general restlessness or excessive movement; more frequent movement from one place to another or having an increased state of activity
Synonyms:exact_synonym: hyperactive;   increased physical activity
 related_synonym: Attention deficit hyperactivity disorder;   restless
 alt_id: MP:0001397;   MP:0001403
 xref: HP:0000752;   HP:0007018


show annotations for term's descendants           Sort by:
hyperactivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrl3 adhesion G protein-coupled receptor L3 IMP compared to wild type RGD PMID:31176715 RGD:127285660 NCBI chr14:26,690,891...27,458,132
Ensembl chr14:26,722,194...27,280,418 		JBrowse link
G Adgrl3em1Huyc adhesion G protein-coupled receptor L3; CRISPR/Cas9 induced mutant1, Huyc IMP compared to wild type RGD PMID:31176715 RGD:127285660
G Cntnap2 contactin associated protein 2 IMP RGD PMID:28364455 PMID:30126973 RGD:12880397, RGD:126790476 NCBI chr 4:75,109,358...77,366,258
Ensembl chr 4:75,109,858...77,366,258 		JBrowse link
G Cntnap2em1Sage contactin associated protein-like 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:28364455 PMID:30126973 RGD:12880397, RGD:126790476
G Fmr1 fragile X messenger ribonucleoprotein 1 IMP compared to wild type controls RGD PMID:38378836 PMID:36581671 RGD:401976422, RGD:401976427 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675 		JBrowse link
G Fmr1em1Sage FMRP translational regulator 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP compared to wild type controls RGD PMID:36581671 RGD:401976427
G Fmr1em2Mcwi FMRP translational regulator 1; CRISPR/Cas9 induced mutant 2, Medical College of Wisconsin IMP RGD PMID:38378836 RGD:401976422
G Myo7a myosin VIIA IAGP DNA:nonsense mutation:cds RGD PMID:15965244 RGD:1581470 NCBI chr 1:161,755,110...161,825,397
Ensembl chr 1:161,755,110...161,825,365 		JBrowse link
G Myo7atnd/Hubr myosin VIIA; ENU induced tornado mutant, Hubr IAGP DNA:nonsense mutation:cds RGD PMID:15965244 RGD:1581470
G Nlgn3 neuroligin 3 IMP RGD PMID:28958035 RGD:126790492 NCBI chr  X:70,469,251...70,497,380
Ensembl chr  X:70,469,457...70,497,379 		JBrowse link
G Nlgn3em1Sage neuroligin 3; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:28958035 RGD:126790492
G Nrxn1 neurexin 1 IMP RGD PMID:25420124 RGD:12914797 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374 		JBrowse link
G Nrxn1em1 neurexin 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:25420124 RGD:12914797
G Shank2 SH3 and multiple ankyrin repeat domains 2 IMP RGD PMID:29970986 RGD:126790534 NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736 		JBrowse link
G Shank2em13Sage SH3 and multiple ankyrin repeat domains 2; ZFN induced mutant13, Sage IMP RGD PMID:29970986 RGD:126790534
increased locomotor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmr1 fragile X messenger ribonucleoprotein 1 IMP RGD PMID:36536454 RGD:401976434 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675 		JBrowse link
G Fmr1em1Sage FMRP translational regulator 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:36536454 RGD:401976434
increased vertical activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlgn3 neuroligin 3 IMP RGD PMID:24773431 RGD:9831152 NCBI chr  X:70,469,251...70,497,380
Ensembl chr  X:70,469,457...70,497,379 		JBrowse link
G Nlgn3em1Sage neuroligin 3; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24773431 RGD:9831152
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta IMP RGD PMID:33479380 RGD:150519900 NCBI chr12:20,606,066...20,738,766
Ensembl chr12:20,618,757...20,738,766 		JBrowse link
G Prkar1bem2Tua protein kinase cAMP-dependent type I regulatory subunit beta; CRISPR/Cas9 induced mutant 2, Tua IMP RGD PMID:33479380 RGD:150519900
G Shank2 SH3 and multiple ankyrin repeat domains 2 IMP RGD PMID:29970986 RGD:126790534 NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:208,598,772...209,018,736 		JBrowse link
G Shank2em13Sage SH3 and multiple ankyrin repeat domains 2; ZFN induced mutant13, Sage IMP RGD PMID:29970986 RGD:126790534
induced hyperactivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 induces IMP compared to wild type littermate RGD PMID:18581099 RGD:4889490 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
G Slc6a4m1Hubr solute carrier family 6 member 4; ZFN induced mutant1, Hubr induces IMP compared to wild type littermate RGD PMID:18581099 RGD:4889490
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5432
    behavior/neurological phenotype 622
      abnormal behavior 621
        abnormal motor capabilities/coordination/movement 240
          abnormal voluntary movement 169
            hyperactivity 47
              increased locomotor activity 3
              increased vertical activity 9
              induced hyperactivity + 4
paths to the root