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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased body weight
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Accession:MP:0001260 term browser browse the term
Definition:greater than normal average weight
Synonyms:exact_synonym: high body weight;   increased weight
 xref: HP:0004324


show annotations for term's descendants           Sort by:
increased body weight term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IAGP RGD PMID:23569176 RGD:8657335 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adora2b adenosine A2B receptor IMP RGD PMID:26385692 RGD:11533328 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adora2bem2Mcwi adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26385692 RGD:11533328
G Alms1 ALMS1, centrosome and basal body associated protein IMP compared to wild type RGD PMID:30385718 RGD:151361229 NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005 		JBrowse link
G Alms1em1Mcwi Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP compared to wild type RGD PMID:30385718 RGD:151361229
G Bdnf brain-derived neurotrophic factor severity IMP compared to WT RGD PMID:23583595 PMID:23583595 RGD:38501054, RGD:38501054 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP compared to WT RGD PMID:23583595 PMID:23583595 RGD:38501054, RGD:38501054
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP in KO rat RGD PMID:30893315 RGD:126908018 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1bem1Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc IMP RGD PMID:30893315 RGD:126908018
G Cdkn1bem4Musc cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc IMP RGD PMID:30893315 RGD:126908018
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 treatment IMP compared to untreated RGD PMID:32231239 RGD:32716373 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp27b1em1Thka cytochrome P450, family 27, subfamily b, polypeptide 1; CRISPR/Cas9 induced mutant 1, Thka treatment IMP compared to untreated RGD PMID:32231239 RGD:32716373
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 induces
onset		 IMP compared to standard diet
compared to wild type		 RGD PMID:29656108 PMID:29656108 RGD:150520032, RGD:150520032 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp2j4em1Sage cytochrome P450, family 2, subfamily j, polypeptide 4, ZFN induced mutant 1, Sage onset
induces		 IMP compared to wild type
compared to standard diet		 RGD PMID:29656108 PMID:29656108 RGD:150520032, RGD:150520032
G Fh fumarate hydratase IMP male only; RGD PMID:27556703 RGD:13792708 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fhem1 fumarate hydratase; TALEN induced mutant 1 IMP male only; RGD PMID:27556703 RGD:13792708
G Gla galactosidase, alpha IMP compared to Wild type females RGD PMID:29979634 RGD:401976416 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664 		JBrowse link
G Glaem2Mcwi galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin IMP compared to Wild type females RGD PMID:29979634 RGD:401976416
G Gper1 G protein-coupled estrogen receptor 1 IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gper1em1Bj G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj IMP compared to wild type SS rat RGD PMID:30354811 RGD:39939000
G Ldlr low density lipoprotein receptor IMP RGD PMID:28469073 RGD:12910100 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage IMP RGD PMID:28469073 RGD:12910100
G Lep leptin IMP RGD PMID:22948215 RGD:12904911 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage IMP RGD PMID:22948215 RGD:12904911
G Lepr leptin receptor sexual_dimorphism
treatment		 IAGP
IMP		 DNA:mutations::cds: : (rat)
compared to BN
compared to ad lib fed rats		 RGD PMID:23154293 PMID:10901178 PMID:20159938 PMID:11500530 PMID:27465994 RGD:13432147, RGD:401965414, RGD:7365117, RGD:628581, RGD:12911217 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:27465994 RGD:12911217
G Leprfa leptin receptor; fa mutant sexual_dimorphism
treatment		 IAGP compared to BN
compared to ad lib fed rats		 RGD PMID:23154293 PMID:20159938 PMID:11500530 RGD:13432147, RGD:7365117, RGD:628581
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:24244710 RGD:12880447 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24244710 RGD:12880447
G Mc4r melanocortin 4 receptor IMP RGD PMID:21527895 PMID:24400148 RGD:6478803, RGD:13825242 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:21527895 PMID:24400148 RGD:6478803, RGD:13825242
G Mecp2 methyl CpG binding protein 2 sexual_dimorphism IMP compared to SD wild-type female RGD PMID:27329765 RGD:40924662 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mecp2em1Sage methyl CpG binding protein 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs sexual_dimorphism IMP compared to SD wild-type female RGD PMID:27329765 RGD:40924662
G Mstn myostatin sexual_dimorphism IMP compared to wild type
compared to wild type male		 RGD PMID:25640143 PMID:27289021 RGD:151347429, RGD:13831345 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Mstnem1Cqin myostatin; ZFN induced mutant 1, Cqin sexual_dimorphism IMP compared to wild type male RGD PMID:27289021 RGD:13831345
G Mstnem1Mcwi myostatin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP compared to wild type RGD PMID:25640143 RGD:151347429
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 IMP RGD PMID:28716828 RGD:13432137 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i2em1Sage nuclear receptor subfamily 1, group I, member 2; ZFN induced mutant1, Sage IMP RGD PMID:28716828 RGD:13432137
G Nrg1 neuregulin 1 IMP RGD PMID:23022220 RGD:39128254 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrg1Tn(sb-T2/Bart3)2.183Mcwi neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin IMP RGD PMID:23022220 RGD:39128254
G Pink1 PTEN induced kinase 1 IMP RGD PMID:24969022 RGD:13210569 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pink1em1Sage PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:24969022 RGD:13210569
G Tnf tumor necrosis factor IAGP RGD PMID:9590569 RGD:1357163 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
obese term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor treatment IAGP compared to heterozygous controls +/fa
compared to age-matched lean heterozygous +/fa rats
compared to ad lib fed rats
DNA:mutations:cds: : (rat)		 RGD PMID:11500530 PMID:9843879 PMID:11500530 PMID:33568522 PMID:32710530 More... RGD:628581, RGD:628910, RGD:628581, RGD:401965412, RGD:401960103, RGD:401965413 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Leprfa leptin receptor; fa mutant treatment IAGP compared to age-matched lean heterozygous +/fa rats
compared to ad lib fed rats
compared to heterozygous controls +/fa		 RGD PMID:9843879 PMID:11500530 PMID:11500530 RGD:628910, RGD:628581, RGD:628581
G Mc4r melanocortin 4 receptor IMP RGD PMID:20531371 RGD:13825198 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr IMP RGD PMID:20531371 RGD:13825198
G Prlhr prolactin releasing hormone receptor IAGP RGD PMID:15854142 RGD:1641829 NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:259,606,704...259,608,391 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5417
    growth/size/body region phenotype 827
      abnormal postnatal growth/weight/body size 629
        abnormal body size 618
          abnormal body weight 603
            increased body weight 334
              obese 19
paths to the root