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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:demyelination
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Accession:MP:0000921 term browser browse the term
Definition:abnormal degeneration or destruction of the myelin sheath that results in the partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract
Comment:Demyelination is a term used to describe the destruction of the myelin sheath that surrounds axonal fibres. This is caused by diseases that damage the myelin sheath or the cells that form it.
Synonyms:exact_synonym: myelin degeneration;   myelin destruction
 alt_id: MP:0010049


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demyelination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klk6 kallikrein related-peptidase 6 IAGP RGD PMID:12023317 RGD:1358596 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121 		JBrowse link
G Tubb4a tubulin, beta 4A class IVa IAGP DNA:missense mutation:cds:p.Ala302Thr (rat) RGD PMID:28393430 RGD:150429639 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5418
    nervous system phenotype 378
      abnormal nervous system physiology 218
        abnormal myelination 33
          demyelination 17
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