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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

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Accession:MP:0000921 term browser browse the term
Definition:abnormal degeneration or destruction of the myelin sheath that results in the partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract
Comment:Demyelination is a term used to describe the destruction of the myelin sheath that surrounds axonal fibres. This is caused by diseases that damage the myelin sheath or the cells that form it.
Synonyms:exact_synonym: myelin degeneration;   myelin destruction
 alt_id: MP:0010049

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demyelination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klk6 kallikrein related-peptidase 6 IAGP RGD PMID:12023317 RGD:1358596 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
JBrowse link
G Tubb4a tubulin, beta 4A class IVa IAGP DNA:missense mutation:cds:p.Ala302Thr (rat) RGD PMID:28393430 RGD:150429639 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5372
    nervous system phenotype 361
      abnormal nervous system physiology 205
        abnormal myelination 33
          demyelination 17
paths to the root