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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:hypertension
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Accession:MP:0000231 term browser browse the term
Definition:sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
Synonyms:narrow_synonym: treatment-resistant hypertension
 alt_id: MP:0001595
 xref: EFO:0000537;   EFO:1002006


show annotations for term's descendants           Sort by:
hypertension term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP-binding cassette, sub-family C member 9 IAGP MGI PMID:12122112 NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041 		JBrowse link
G Ace2 angiotensin converting enzyme 2 IAGP MGI PMID:16878172 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acvrl1 activin A receptor, type II-like 1 IAGP MGI PMID:26398936 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Ada adenosine deaminase IAGP MGI PMID:25538227 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Add2 adducin 2 IAGP MGI PMID:10988280 NCBI chr 6:86,005,663...86,101,391
Ensembl chr 6:86,005,663...86,101,391 		JBrowse link
G Agt angiotensinogen IAGP MGI PMID:11606482 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 IAGP MGI PMID:23023372 NCBI chr15:10,358,602...10,410,244
Ensembl chr15:10,358,618...10,410,239 		JBrowse link
G Apob apolipoprotein B IAGP MGI PMID:18160459 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoe apolipoprotein E IAGP MGI PMID:18160459 PMID:22185842 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 IAGP MGI PMID:27821757 NCBI chr 6:5,383,386...5,433,022
Ensembl chr 6:5,383,386...5,433,022 		JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit IAGP MGI PMID:11296258 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164 		JBrowse link
G Chat choline O-acetyltransferase IAGP MGI PMID:23374353 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Chga chromogranin A IAGP MGI PMID:16007257 NCBI chr12:102,521,200...102,531,286
Ensembl chr12:102,521,228...102,531,287 		JBrowse link
G Comt catechol-O-methyltransferase IAGP MGI PMID:18469803 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Corin corin, serine peptidase IAGP MGI PMID:15637153 NCBI chr 5:72,457,291...72,661,884
Ensembl chr 5:72,457,368...72,661,816 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IAGP MGI PMID:12032352 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001 		JBrowse link
G Cth cystathionine gamma lyase IAGP MGI PMID:18948540 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714 		JBrowse link
G Cul3 cullin 3 IAGP MGI PMID:26286618 NCBI chr 1:80,242,640...80,318,426
Ensembl chr 1:80,242,640...80,318,197 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IAGP MGI PMID:22185842 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 IAGP MGI PMID:16691295 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Drd5 dopamine receptor D5 IAGP MGI PMID:12486173 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Edn1 endothelin 1 IAGP MGI PMID:15314687 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Eln elastin IAGP MGI PMID:14597767 NCBI chr 5:134,731,449...134,776,300
Ensembl chr 5:134,731,447...134,776,177 		JBrowse link
G Fkbp1b FK506 binding protein 1b IAGP MGI PMID:11907581 NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591 		JBrowse link
G Fstl3 follistatin-like 3 IAGP MGI PMID:17229845 NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464 		JBrowse link
G Gata5 GATA binding protein 5 IAGP MGI PMID:26617239 NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 IAGP MGI PMID:20065162 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F IAGP MGI PMID:31673025 NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene IAGP MGI PMID:18483625 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IAGP MGI PMID:10074485 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Irs1 insulin receptor substrate 1 IAGP MGI PMID:9541510 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 IAGP MGI PMID:23974906 NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340 		JBrowse link
G Kcnk3 potassium channel, subfamily K, member 3 IAGP MGI PMID:18250325 NCBI chr 5:30,745,514...30,782,614
Ensembl chr 5:30,745,514...30,782,615 		JBrowse link
G Kcnk6 potassium inwardly-rectifying channel, subfamily K, member 6 IAGP MGI PMID:21876070 NCBI chr 7:28,921,353...28,931,947
Ensembl chr 7:28,921,351...28,931,940 		JBrowse link
G Kcnk9 potassium channel, subfamily K, member 9 IAGP MGI PMID:18250325 NCBI chr15:72,373,722...72,422,415
Ensembl chr15:72,372,938...72,418,189 		JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:15864294 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
G Ldlr low density lipoprotein receptor IAGP MGI PMID:18160459 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lep leptin IAGP MGI PMID:18160459 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Map3k15 mitogen-activated protein kinase kinase kinase 15 IAGP MGI PMID:23250415 NCBI chr  X:158,771,200...158,906,342
Ensembl chr  X:158,771,429...158,906,347 		JBrowse link
G Mc4r melanocortin 4 receptor IAGP MGI PMID:23374353 NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577 		JBrowse link
G Mir503hg Mir503, Mir351, and Mir322 host gene IAGP MGI PMID:36929003 NCBI chr  X:52,141,989...52,146,067
Ensembl chr  X:52,141,992...52,146,093
Ensembl chr  X:52,141,992...52,146,093 		JBrowse link
G Mpv17 MpV17 mitochondrial inner membrane protein IAGP MGI PMID:10673153 NCBI chr 5:31,298,007...31,311,595
Ensembl chr 5:31,297,998...31,311,595 		JBrowse link
G Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like IAGP MGI PMID:18524855 NCBI chr18:65,017,551...65,350,888
Ensembl chr18:65,020,776...65,350,899 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal IAGP MGI PMID:16024729 PMID:18413498 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible IAGP MGI PMID:16024729 PMID:18413498 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell IAGP MGI PMID:7545787 PMID:9468189 PMID:10435012 PMID:10652188 PMID:11457755 More... NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nppa natriuretic peptide type A IAGP MGI PMID:7839143 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP MGI PMID:12124219 NCBI chr 3:90,357,898...90,373,235
Ensembl chr 3:90,357,898...90,373,173 		JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 IAGP MGI PMID:10638758 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026 		JBrowse link
G Pax8 paired box 8 IAGP MGI PMID:31673025 NCBI chr 2:24,310,563...24,365,611
Ensembl chr 2:24,310,572...24,365,611 		JBrowse link
G Pdc phosducin IAGP MGI PMID:19959875 NCBI chr 1:150,195,168...150,209,657
Ensembl chr 1:150,195,168...150,209,657 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase IAGP MGI PMID:17698731 NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IAGP MGI PMID:15254591 PMID:15716267 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I IAGP MGI PMID:9606187 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
G Pvalb parvalbumin IAGP MGI PMID:28442491 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600 		JBrowse link
G Slc12a6 solute carrier family 12, member 6 IAGP MGI PMID:14532115 NCBI chr 2:112,096,659...112,193,508
Ensembl chr 2:112,096,170...112,193,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 IAGP MGI PMID:9334720 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 IAGP MGI PMID:25100214 NCBI chr 5:38,506,616...38,660,488
Ensembl chr 5:38,506,616...38,660,486 		JBrowse link
G Slc6a18 solute carrier family 6 (neurotransmitter transporter), member 18 IAGP MGI PMID:15121838 NCBI chr13:73,809,869...73,826,142
Ensembl chr13:73,809,871...73,826,142 		JBrowse link
G Stk39 serine/threonine kinase 39 IAGP MGI PMID:28442491 NCBI chr 2:68,040,789...68,302,381
Ensembl chr 2:68,040,789...68,302,612 		JBrowse link
G Tal1 T cell acute lymphocytic leukemia 1 IAGP MGI PMID:1836514 NCBI chr 4:114,913,623...114,928,952
Ensembl chr 4:114,913,623...114,928,952 		JBrowse link
G Tlr5 toll-like receptor 5 IAGP MGI PMID:20203013 NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010 		JBrowse link
G Vav2 vav 2 oncogene IAGP MGI PMID:17202406 NCBI chr 2:27,152,116...27,317,620
Ensembl chr 2:27,152,116...27,317,045 		JBrowse link
G Vav3 vav 3 oncogene IAGP MGI PMID:16767097 NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IAGP MGI PMID:12122115 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vgf VGF nerve growth factor inducible IAGP MGI PMID:24497580 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 IAGP MGI PMID:17488636 PMID:30765526 NCBI chr11:101,151,363...101,168,235
Ensembl chr11:101,151,393...101,168,235 		JBrowse link
decreased susceptibility to hypertension term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 IAGP MGI PMID:33890822 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288 		JBrowse link
G Rcn2 reticulocalbin 2 IAGP MGI PMID:30943068 NCBI chr 9:55,949,129...55,966,367
Ensembl chr 9:55,949,129...55,969,166 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IAGP MGI PMID:24135024 NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 IAGP MGI PMID:31815093 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Umod uromodulin IAGP MGI PMID:24324041 NCBI chr 7:119,061,931...119,078,485
Ensembl chr 7:119,061,934...119,078,505 		JBrowse link
increased susceptibility to hypertension term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5r3 cytochrome b5 reductase 3 IAGP MGI PMID:31487266 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793 		JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 IAGP MGI PMID:26168216 NCBI chr10:81,364,558...81,380,996
Ensembl chr10:81,364,558...81,381,024 		JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide IAGP MGI PMID:26168216 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827 		JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 IAGP MGI PMID:26168216 NCBI chr 7:100,645,775...100,661,260
Ensembl chr 7:100,645,775...100,662,073 		JBrowse link
G Stox1 storkhead box 1 IAGP MGI PMID:33301424 NCBI chr10:62,494,822...62,561,907
Ensembl chr10:62,494,822...62,561,907 		JBrowse link
salt-resistant hypertension term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Guca2b guanylate cyclase activator 2b IAGP MGI PMID:14561709 NCBI chr 4:119,513,798...119,516,142
Ensembl chr 4:119,513,804...119,516,151 		JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP MGI PMID:7477288 PMID:9405681 NCBI chr 3:90,357,898...90,373,235
Ensembl chr 3:90,357,898...90,373,173 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I IAGP MGI PMID:18448676 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
salt-sensitive hypertension term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase IAGP MGI PMID:15637153 NCBI chr 5:72,457,291...72,661,884
Ensembl chr 5:72,457,368...72,661,816 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 IAGP MGI PMID:22184322 NCBI chr19:43,993,461...44,017,695
Ensembl chr19:43,993,461...44,017,647 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 IAGP MGI PMID:16691295 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Ddc dopa decarboxylase IAGP MGI PMID:21701066 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Edn1 endothelin 1 IAGP MGI PMID:15314687 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Gata5 GATA binding protein 5 IAGP MGI PMID:26617239 NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492 		JBrowse link
G Klhl3 kelch-like 3 IAGP MGI PMID:24821705 PMID:28052936 NCBI chr13:58,148,040...58,271,288
Ensembl chr13:58,148,042...58,261,406 		JBrowse link
G Map3k15 mitogen-activated protein kinase kinase kinase 15 IAGP MGI PMID:23250415 NCBI chr  X:158,771,200...158,906,342
Ensembl chr  X:158,771,429...158,906,347 		JBrowse link
G Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like IAGP MGI PMID:18524855 NCBI chr18:65,017,551...65,350,888
Ensembl chr18:65,020,776...65,350,899 		JBrowse link
G Nppa natriuretic peptide type A IAGP MGI PMID:7839143 PMID:9458926 PMID:10484477 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Pvalb parvalbumin IAGP MGI PMID:28442491 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600 		JBrowse link
G Scnn1b sodium channel, nonvoltage-gated 1 beta IAGP MGI PMID:10589691 NCBI chr 7:121,464,261...121,517,951
Ensembl chr 7:121,464,261...121,517,737 		JBrowse link
G Stk39 serine/threonine kinase 39 IAGP MGI PMID:28442491 NCBI chr 2:68,040,789...68,302,381
Ensembl chr 2:68,040,789...68,302,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    cardiovascular system phenotype 4114
      abnormal cardiovascular system physiology 2375
        abnormal systemic arterial blood pressure 311
          increased systemic arterial blood pressure 204
            hypertension 91
              decreased susceptibility to hypertension 5
              increased susceptibility to hypertension 5
              salt-resistant hypertension 3
              salt-sensitive hypertension 18
paths to the root