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The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (

Term:active avoidance test using a two-way shuttle box apparatus
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Accession:MMO:0000302 term browser browse the term
Definition:Active avoidance requires performing a specific behavior in order to escape or avoid the aversive stimulus. It is a conditioning paradigm in which the animal learns to control the application of an unconditioned stimulus (US), in this case, a foot shock, by appropriately reacting to a conditioned stimulus (CS) preceding the US, such as a light cue. The first stage of avoidance learning is usually to escape from the US. With continued training, anticipatory reactions appear which enable the animal to avoid the US altogether. In the active avoidance test, the rodent is placed into a shuttle box and is trained to move to the opposite side of the box in response to a cue that signals an incoming foot shock. Movement to the opposite side of the chamber in response to the presentation of the shock-predictive cue alone is regarded as active avoidance, whereas movement to the opposite side of the chamber only after receiving foot shock is regarded as an escape response.

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active avoidance test using a two-way shuttle box apparatus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
Q Anxrr21 Anxiety related response QTL 21 IDA RGD PMID:18971309 RGD:2313899 NCBI chr 5:66,174,080...124,160,948 JBrowse link

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  measurement method 2368
    in vivo method 1105
      body movement/behavior method 104
        movement/behavior test apparatus method 90
          movement/behavior test enclosure method 39
            two way shuttlebox apparatus method 1
              active avoidance test using a two-way shuttle box apparatus 1
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