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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Subcortical U fiber lesion
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Accession:HP:6000995 term browser browse the term
Definition:Abnormal morphology of subcortical U fibers, typically as assessed by abnromal intensity on magnetic resonance imaging of the brain.
Comment:Subcortical U-fibers are special types of short association fibers located in the superficial white matter (SWM). In contrast to the SWM, the U-fibers only connect the adjacent gyri. Since U-fibers have a rich blood supply from long perforating arteries and short perforating arteries that span the white matter (WM) and adjacent cortex, they are usually unaffected in chronic ischemic WM disease. Anatomically, U-fibers originate from pyramidal neurons of layer 6 of the cerebral cortex and provide local integration of different sites of the same gyrus or immediately adjacent gyri. Developmentally, U-fibers do not fork until the second half of gestation when gyration and sulcation of the cerebral cortex occur. As a result, U-fibers are not readily involved in diseases of myelin metabolism, such as adrenoleukodystrophy and metachromatic leukodystrophy. However, in demyelinating diseases with normal myelin and oligodendrocyte dominance, including multiple sclerosis and progressive multifocal leukoencephalopathy, U-fibers are commonly involved Pathologic processes that involve the white matter typically appear hyperintense on T2/FLAIR images.
Synonyms:exact_synonym: Subcortical U fiber involvement


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal brain morphology 0
              Abnormal forebrain morphology 0
                Abnormal cerebral morphology 0
                  Abnormal cerebral subcortex morphology 0
                    Subcortical U fiber lesion 0
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