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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Terminal hepatic lobular vascular occlusion
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Accession:HP:6000716 term browser browse the term
Definition:A type of Hepatic venous outflow obstruction characterized by fibrous concentric narrowing of zone 3 terminal hepatic venules, centrilobular hepatocyte necrosis, and sinusoidal congestion, accomapnied by necrosis of pericentral hepatocytes, and narrowing and eventual fibrosis of central veins.
Comment:Hepatic veno-occlusive disease (VOD) may present with fragmented red blood cells, fibrinogen, and Factor VIII/von Willebrand factor can be demonstrated in the subendothelial space of central veins and perivenular zones of hepatic acini. In the later stages, sinusoidal and venous lumen become obliterated by typeI, III, and IV collagen accompanied by an increase in the stellate cells that line the sinusoids. In some cases, fibrous bridges between central venules are observed.
Synonyms:exact_synonym: Hepatic sinusoidal obstruction syndrome;   Hepatic veno-occlusive disease


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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the cardiovascular system 0
        Abnormality of the vasculature 0
          Abnormality of the hepatic vasculature 0
            Terminal hepatic lobular vascular occlusion 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormality of the abdominal organs 0
          Abnormality of the liver 0
            Abnormal liver morphology 0
              Abnormality of the hepatic vasculature 0
                Terminal hepatic lobular vascular occlusion 0
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