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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Desmoid tumors
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Accession:HP:0100245 term browser browse the term
Definition:Benign, slow-growing tumors without any metastatic potential. Despite their benign nature, they can damage nearby structures causing organ dysfunction. Histologically they resemble low-grade fibrosarcomas, but they are very locally aggressive and tend to recur even after complete resection. There is a tendency for recurrence in the setting of prior surgery and the most common localisation of these tumors is intraabdominal from smooth muscle cells of the instestine.
Comment:Most cases are sporadic, but some are associated with familial adenomatous polyposis (FAP). Approximately 10% of individuals with Gardner's syndrome, a type of FAP with extracolonic features, have desmoid tumors. Risk factors for desmoid disease amongst FAP patients include female gender, a 3' APC mutation, a positive family history and a history of previous abdominal surgery.
Synonyms:exact_synonym: Desmoid tumours
 xref: MESH:D018222;   NCI:C3042;   SNOMEDCT_US:399994005;   SNOMEDCT_US:400055004;   SNOMEDCT_US:47284001;   UMLS:C0079218

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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormality of the gastrointestinal tract 0
          Neoplasm of the gastrointestinal tract 0
            Desmoid tumors 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Neoplasm 0
        Neoplasm by histology 0
          Sarcoma 0
            Soft tissue sarcoma 0
              Fibroma 0
                Desmoid tumors 0
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