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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Phonic tics
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Accession:HP:0100035 term browser browse the term
Definition:Tics are defined as movements or sounds that resemble physiological motor behaviors, but are typically inopportune to social context and appear sudden, repetitive, and often exaggerated. Tic vocalizations commonly termed vocal or phonic tics may include any possible sound (eg, sniffing, coughing, throat clearing, whistling, or grunting), word, or sentence and are most commonly encountered within the spectrum of primary tic disorders, as Tourette syndrome.
Comment:In Tourette syndrome (TS), affected individuals have tics, including phonic and vocal behaviors, that are typically preceded by premonitory urges and can be suppressed voluntarily. Individuals with autism spectrum disorders (ASD) may also present with vocal tics. However, in ASD premonitory urges and overall vocal tic awareness may be reduced compared to people with primary tic disorders and TS. Phonic tics have been described in a variety of other disorders including Klinefelter, fragile X, and Adams-Oliver syndrome, monosomy 9p and trisomy 16p, neurodegenerative syndromes such as Huntington disease. Furthermore, chorea-acanthocytosis because of VPS13A mutations, Amyotrophic lateral sclerosis frontotemporal dementia overlap syndromes, progressive supranuclear palsy, and pantothenate kinase-associated neurodegeneration may present with vocal tics. Neurometabolic disorders such as Wilson's disease or phenylketonuria, focal brain lesions, infectious, and other autoimmune diseases are additional causes of vocal tics. Finally, phonic or vocal tics may also be drug-induced, either directly related to the acute effects of drugs (e.g., cocaine) or as a long-term consequence, such as in tardive tic disorders.
Synonyms:exact_synonym: Verbal tics;   Vocal tics
 xref: UMLS:C0751901


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system physiology 0
          Abnormal central motor function 0
            Involuntary vocalization 0
              Phonic tics 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system physiology 0
          Abnormality of mental function 0
            Atypical behavior 0
              Recurrent maladaptive behavior 0
                Compulsive behaviors 0
                  Tics 0
                    Phonic tics 0
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