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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Neural tube defect
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Accession:HP:0045005 term browser browse the term
Definition:A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine.
Synonyms:exact_synonym: Abnormality of neural tube closure
 xref: MESH:D009436;   SNOMEDCT_US:253098009;   UMLS:C0027794



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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal neural tube morphology 0
              Neural tube defect 0
                Closed neural tube defect + 0
                Open neural tube defect + 0
                Spinal dysraphism + 0
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