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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Ductus venosus agenesis
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Accession:HP:0034196 term browser browse the term
Definition:A developmental defect characterized by lack of formation of the ductus venosus (a shunt that allows oxygenated blood in the umbilical vein to bypass the liver in the fetal circulation).
Comment:The ductus venosus (DV) plays an essential role in the fetal circulation because it allows the oxygenated placental blood to bypass the liver and enables preferential flow via the right atrium and foramen ovale to the left atrium. Furthermore, normal umbilical flow via DV is involved in the normal development of the intrahepatic portal venous system. The lack of critical anastomoses between the portal and umbilical venous system and hepatic-systemic venous system results in agenesis of ductus venosus and shunting of umbilical blood through an aberrant vessel. Between 1 in 2532 to 1 in 556 fetuses are affected.
Synonyms:exact_synonym: Agenesis of the ductus venosus



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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the cardiovascular system 0
        Abnormality of cardiovascular system morphology 0
          Abnormal fetal cardiovascular morphology 0
            Ductus venosus agenesis 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of prenatal development or birth 0
        Fetal anomaly 0
          Abnormal fetal morphology 0
            Abnormal fetal cardiovascular morphology 0
              Ductus venosus agenesis 0
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