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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Progressive massive fibrosis
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Accession:HP:0033706 term browser browse the term
Definition:This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in\nthe upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis.
Comment:See Figure 56 of Hansell DM, et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008;246:697-722.

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  Human phenotype 15292
    Phenotypic abnormality 15290
      Abnormality of the respiratory system 2481
        Abnormal respiratory system morphology 1501
          Abnormal pulmonary thoracic imaging finding 151
            Progressive massive fibrosis 0
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