Glomerular basement membrane disruption - Ontology Report

HUMAN PHENOTYPE - ANNOTATIONS	{{ watchLinkText }}
The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:	Glomerular basement membrane disruption	go back to main search page
Accession:	HP:0033485	browse the term
Definition:	A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver.
Comment:	Disruption of the glomerular basement membrane (GBM) may occur in settings of inflammation (ANCA/antiGBM antibodies) or could be seen due to structural weakness of the GBM (Collagen IV disorders). This feature can be associated with extracapillary fibrin. The definition of this term intends to exclude glomeruli at the edge of the core where rupture could be iatrogenic or mechanical.
Synonyms:	exact_synonym:	Disruption of the glomerular basement membrane; Glomerular basement membrane rupture

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Genes (1)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CD151

CD151 molecule (Raph blood group)

NCBI chr11:832,952...838,831
Ensembl chr11:832,887...839,831

Term paths to the root

Path 1
Term	Annotations
Human phenotype	21554
Phenotypic abnormality	21544
Abnormality of the genitourinary system	4407
Abnormality of the urinary system	2338
Abnormality of the upper urinary tract	1704
Abnormality of the kidney	1672
Abnormal renal morphology	1263
Abnormal nephron morphology	299
Abnormal renal glomerulus morphology	236
Abnormal glomerular basement membrane morphology	12
Glomerular basement membrane disruption	1
Path 2
Term	Annotations
Human phenotype	21554
Phenotypic abnormality	21544
Abnormality of the genitourinary system	4407
Abnormality of the urinary system	2338
Abnormality of the upper urinary tract	1704
Abnormality of the kidney	1672
Abnormal renal morphology	1263
Abnormal renal cortex morphology	278
Abnormal renal corpuscle morphology	237
Abnormal renal glomerulus morphology	236
Glomerular deposits	21
Glomerular subepithelial deposits	13
Abnormal glomerular basement membrane morphology	12
Glomerular basement membrane disruption	1

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