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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Pulmonary necrosis
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Accession:HP:0033243 term browser browse the term
Definition:Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components.
Comment:Cell blebbing (bulky morphology of the cell, disruptin of cell membranes and organelles) and nucleus changes (shrunken nucleus fragments and chromatin condesation) is visible with electron microscope and DAPI staining. The release of cell contents initiates an inflammatory response in the surrounding tissue is detectable with hematoxylin and eosin staining.

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the respiratory system 0
        Abnormal respiratory system physiology 0
          Abnormal respiratory system morphology 0
            Abnormal lung morphology 0
              Abnormal pulmonary interstitial morphology 0
                Pulmonary necrosis 0
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