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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormal plasmablast proportion
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Accession:HP:0032127 term browser browse the term
Definition:Abnormal increase or decrease of plasmablasts, commonly characterized as CD27+CD38hi and sometimes additionally as IgMlowCD24-, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
Comment:Differentiation of B cells into plasmablasts (PB) is most commonly monitored with surface markers CD19, CD20, CD27, CD38, and CD138 and intracellular marker Ki-67. Plasmablasts are antibody-secreting cells that originate after infection or vaccination.


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormal leukocyte morphology 0
          Abnormal lymphocyte morphology 0
            Abnormal B cell morphology 0
              Abnormal B cell subset distribution 0
                Abnormal plasmablast proportion 0
                  Decreased proportion of plasmablasts 0
                  Increased proportion of plasmablasts 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormal immune system morphology 0
          Abnormal cellular immune system morphology 0
            Abnormal leukocyte morphology 0
              Abnormal lymphocyte morphology 0
                Abnormal B cell morphology 0
                  Abnormal B cell subset distribution 0
                    Abnormal plasmablast proportion 0
                      Decreased proportion of plasmablasts 0
                      Increased proportion of plasmablasts 0
paths to the root