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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Megakaryocyte nucleus hypolobulation
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Accession:HP:0031385 term browser browse the term
Definition:The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus.
Comment:Megakaryocytes with a hypolobulated nucleus can be seen in normal bone marrow but numbers are increased in some patients with myelodysplastic syndrome.

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormality of bone marrow cell morphology 0
          Abnormal megakaryocyte morphology 0
            Megakaryocyte nucleus hypolobulation 0
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