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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Cardiomyocyte hypertrophy
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Accession:HP:0031319 term browser browse the term
Definition:An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes.
Comment:Adult cardiac myocytes are highly specialized, terminally differentiated cells which have lost the ability to divide. The increase in heart muscle mass seen in cardiac hypertrophy occurs predominantly through an increase in myocyte size rather than number. Hypertrophy is the principal response of the heart to overload from any cause, including hypertension, myocardial infarction, valvar heart disease, and dilated cardiomyopathy.
Synonyms:exact_synonym: Myocyte cellular hypertrophy


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormal cellular phenotype 0
        Abnormal cell morphology 0
          Abnormal cardiomyocyte morphology 0
            Cardiomyocyte hypertrophy 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the cardiovascular system 0
        Abnormal cardiovascular system morphology 0
          Abnormal heart morphology 0
            Abnormal cardiomyocyte morphology 0
              Cardiomyocyte hypertrophy 0
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