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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Granulomatous cholangitis
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Accession:HP:0030988 term browser browse the term
Definition:Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts.
Comment:Granulomatous cholangitis involving the interlobular bile ducts constitutes the hallmark of primary biliary cholangitis and is also found in drug-induced liver disease and sarcoidosis.

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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Abnormal inflammatory response 0
            Increased inflammatory response 0
              Cholangitis 0
                Granulomatous cholangitis 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormality of the abdominal organs 0
          Abnormality of the liver 0
            Abnormality of the biliary system 0
              Biliary tract abnormality 0
                Abnormal biliary tract morphology 0
                  Cholangitis 0
                    Granulomatous cholangitis 0
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