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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Granulomatous cholangitis
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Accession:HP:0030988 term browser browse the term
Definition:Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts.
Comment:Granulomatous cholangitis involving the interlobular bile ducts constitutes the hallmark of primary biliary cholangitis and is also found in drug-induced liver disease and sarcoidosis.


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Path 1
Term Annotations click to browse term
  Human phenotype 74032
    Phenotypic abnormality 73727
      Abnormality of the immune system 10736
        Abnormality of immune system physiology 8023
          Abnormal inflammatory response 5905
            Increased inflammatory response 5878
              Cholangitis 341
                Granulomatous cholangitis 0
Path 2
Term Annotations click to browse term
  Human phenotype 74032
    Phenotypic abnormality 73727
      Abnormality of the digestive system 10593
        Abnormality of the abdominal organs 3313
          Abnormality of the liver 2679
            Abnormality of the biliary system 1358
              Biliary tract abnormality 764
                Abnormal biliary tract morphology 750
                  Cholangitis 341
                    Granulomatous cholangitis 0
paths to the root