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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Airway casts
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Accession:HP:0025696 term browser browse the term
Definition:A replicate of airways from accumulated and condensed mucous and cellular material. These semisolid occlusions take the shape of the airway within they are formed, leading to obstruction of the tracheobronchial tree with consecutive respiratory insufficiency. Based on their principal composition, one can differentiate fibrin casts and mucin casts. Plastic bronchitis is the name of the condition characterized by the formation of airway casts.
Comment:Casts are frequently (4-16%) observed in patients with congenital heart disease who have undergone Fontan palliation. Casts are infrequently observed in sickle cell disease-and acute chest syndrome, airway infections, in particular H1N1 influenza, severe asthma, or after smoke/chemical inhalation injuries.

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the respiratory system 0
        Abnormal respiratory system physiology 0
          Abnormal respiratory system morphology 0
            Abnormal tracheobronchial morphology 0
              Abnormal bronchus morphology 0
                Airway casts 0
                  Fibrin casts 0
                  Mucin casts 0
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