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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Persistent human papillomavirus infection
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Accession:HP:0020114 term browser browse the term
Definition:Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease.
Synonyms:exact_synonym: Chronic HPV infection;   Persistent HPV infection;   chronic human papillomavirus infection
 broad_synonym: human papilloma virus infection
 xref: EFO:0001668;   EFO:0010060

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Unusual infection 0
            Severe infection 0
              Persistent human papillomavirus infection 0
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