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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormality of the common coagulation pathway
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Accession:HP:0010990 term browser browse the term
Definition:An abnormality of blood coagulation, common pathway.
Comment:The common pathway is a protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex.
Synonyms:xref: UMLS:C4023609


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormality of coagulation 0
          Abnormality of the coagulation cascade 0
            Abnormality of the common coagulation pathway 0
              Abnormal coagulation factor V activity + 0
              Abnormality of circulating fibrinogen + 0
              Decreased level of heparin co-factor II 0
              Decreased level of histidine-rich glycoprotein 0
              Decreased level of plasminogen 0
              Decreased level of thrombomodulin 0
              Decreased level of tissue plasminogen activator 0
              Increased plasma vitamin K epoxide after vitamin K supplementation 0
              Prolonged Russell's viper venom time 0
              Reduced alpha-2-antiplasmin activity 0
              Reduced antithrombin antigen 0
              Reduced factor X activity + 0
              Reduced factor XIII activity + 0
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