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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Recurrent gram-negative bacterial infections
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Accession:HP:0005420 term browser browse the term
Definition:Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents.
Comment:Gram-negative bacteria have a unique outer membrane, a thinner layer of peptidoglycan compared to gram-positive bacteria, and a periplasmic space between the cell wall and the membrane.
Synonyms:alt_id: HP:0005395
 xref: UMLS:C4025198

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Unusual infection 0
            Recurrent infections 0
              Recurrent bacterial infections 0
                Recurrent gram-negative bacterial infections 0
                  Recurrent Burkholderia cepacia infections 0
                  Recurrent E. coli infections 0
                  Recurrent Haemophilus influenzae infections 0
                  Recurrent Klebsiella infections 0
                  Recurrent Neisserial infections + 0
                  Recurrent Serratia marcescens infections 0
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