Term: Impaired mastication
Accession: HP:0005216
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Definition: An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.
Comment: Chewing and swallowing are interrelated. The act of chewing plays a fundamental role in the process of swallowing food. Mastication prepares food for swallowing by breaking it into small particles. Accordingly, loss of teeth has been associated with swallowing difficulties. Chewing difficulties may be caused by loss of teeth, partial dentures, or by tooth pain. Swallowing difficulties, in contrast, are often characterized by difficulties swallowing liquids, reflux, throat spasms, choking on dry food, or dysphagia.
Synonyms: exact_synonym: Chewing difficulties; Chewing difficulty
xref: SNOMEDCT_US:162020001; UMLS:C0239043
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ACTA1
actin alpha 1, skeletal muscle
IAGP
HPO
ORPHA:2020
NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104
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ADNP
activity dependent neuroprotector homeobox
IAGP
HPO
ORPHA:404448
NCBI chr20:50,888,918...50,931,437
Ensembl chr20:50,888,916...50,931,437
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ADSS1
adenylosuccinate synthase 1
IAGP
HPO
ORPHA:482601
NCBI chr14:104,724,229...104,747,325
Ensembl chr14:104,724,174...104,747,325
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ALS2
alsin Rho guanine nucleotide exchange factor ALS2
IAGP
HPO
OMIM:607225 ORPHA:293168
NCBI chr 2:201,700,267...201,780,933
Ensembl chr 2:201,700,267...201,782,112
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AXIN2
axin 2
IAGP
HPO
ORPHA:99798
NCBI chr17:65,528,563...65,561,648
Ensembl chr17:65,528,563...65,561,648
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CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
IAGP
HPO
OMIM:601462
NCBI chr 2:174,747,592...174,764,472
Ensembl chr 2:174,747,592...174,787,935
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COLQ
collagen like tail subunit of asymmetric acetylcholinesterase
IAGP
HPO
ORPHA:98915
NCBI chr 3:15,450,133...15,521,706
Ensembl chr 3:15,450,133...15,521,751
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EDA
ectodysplasin A
IAGP
HPO
ORPHA:99798
NCBI chr X:69,616,113...70,039,472
Ensembl chr X:69,616,067...70,039,472
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EDARADD
EDAR associated via death domain
IAGP
HPO
ORPHA:99798
NCBI chr 1:236,348,259...236,484,930
Ensembl chr 1:236,348,257...236,502,915
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FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
IAGP
HPO
ORPHA:466722
NCBI chr 6:5,249,934...5,771,583
Ensembl chr 6:5,261,044...5,829,192
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FGFR1
fibroblast growth factor receptor 1
IAGP
HPO
ORPHA:99798
NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
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GNAI3
G protein subunit alpha i3
IAGP
HPO
OMIM:602483
NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
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GRIN1
glutamate ionotropic receptor NMDA type subunit 1
IAGP
HPO
ORPHA:208447
NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
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H4C5
H4 clustered histone 5
IAGP
HPO
OMIM:619950
NCBI chr 6:26,204,610...26,205,021
Ensembl chr 6:26,204,610...26,205,021
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HACD1
3-hydroxyacyl-CoA dehydratase 1
IAGP
HPO
ORPHA:2020
NCBI chr10:17,589,032...17,617,374
Ensembl chr10:17,589,032...17,617,374
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HLA-B
major histocompatibility complex, class I, B
IAGP
HPO
ORPHA:397
NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
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HLA-DRB1
major histocompatibility complex, class II, DR beta 1
IAGP
HPO
ORPHA:397
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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HOXB1
homeobox B1
IAGP
HPO
OMIM:614744
NCBI chr17:48,528,526...48,531,011
Ensembl chr17:48,528,526...48,531,011
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IDS
iduronate 2-sulfatase
IAGP
HPO
ORPHA:217085 ORPHA:217093
NCBI chr X:149,476,988...149,505,306
Ensembl chr X:149,476,988...149,521,096
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IRF6
interferon regulatory factor 6
IAGP
HPO
ORPHA:141291 ORPHA:99798
NCBI chr 1:209,785,617...209,806,142
Ensembl chr 1:209,785,617...209,806,175
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ITGA7
integrin subunit alpha 7
IAGP
HPO
ORPHA:2020
NCBI chr12:55,684,568...55,716,400
Ensembl chr12:55,684,568...55,716,404
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KANSL1
KAT8 regulatory NSL complex subunit 1
IAGP
HPO
ORPHA:363958 ORPHA:363965
NCBI chr17:46,029,916...46,225,367
Ensembl chr17:46,029,916...46,225,389
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LAMA2
laminin subunit alpha 2
IAGP
HPO
ORPHA:258
NCBI chr 6:128,883,138...129,516,566
Ensembl chr 6:128,883,138...129,516,566
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LAMB2
laminin subunit beta 2
IAGP
HPO
ORPHA:98915
NCBI chr 3:49,121,114...49,133,050
Ensembl chr 3:49,121,114...49,133,118
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LPIN1
lipin 1
IAGP
HPO
ORPHA:99845
NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
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LRP6
LDL receptor related protein 6
IAGP
HPO
ORPHA:99798
NCBI chr12:12,116,025...12,267,044
Ensembl chr12:12,116,025...12,267,044
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MAP3K20
mitogen-activated protein kinase kinase kinase 20
IAGP
HPO
ORPHA:2020
NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015
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MSX1
msh homeobox 1
IAGP
HPO
ORPHA:141291 ORPHA:99798
NCBI chr 4:4,859,665...4,863,936
Ensembl chr 4:4,859,665...4,863,936
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MT-CO1
mitochondrially encoded cytochrome c oxidase I
IAGP
HPO
ORPHA:99845
NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
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MT-CO3
mitochondrially encoded cytochrome c oxidase III
IAGP
HPO
ORPHA:99845
NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990
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MTRFR
mitochondrial translation release factor in rescue
IAGP
HPO
OMIM:613559 ORPHA:254930
NCBI chr12:123,232,914...123,257,960
Ensembl chr12:123,233,385...123,258,079
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MYL2
myosin light chain 2
IAGP
HPO
ORPHA:2020
NCBI chr12:110,910,845...110,921,449
Ensembl chr12:110,910,819...110,921,443
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NAA20
N-alpha-acetyltransferase 20, NatB catalytic subunit
IAGP
HPO
OMIM:619717
NCBI chr20:20,017,290...20,033,655
Ensembl chr20:20,017,310...20,033,655
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NECTIN1
nectin cell adhesion molecule 1
IAGP
HPO
ORPHA:141291
NCBI chr11:119,638,098...119,729,200
Ensembl chr11:119,623,408...119,729,200
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NEUROG1
neurogenin 1
IAGP
HPO
OMIM:620469
NCBI chr 5:135,534,282...135,535,964
Ensembl chr 5:135,534,282...135,535,964
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OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
IAGP
HPO
ORPHA:99845
NCBI chr 1:228,208,044...228,378,876
Ensembl chr 1:228,208,044...228,378,876
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P4HA2
prolyl 4-hydroxylase subunit alpha 2
IAGP
HPO
ORPHA:397
NCBI chr 5:132,190,147...132,227,853
Ensembl chr 5:132,190,147...132,295,315
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PAX9
paired box 9
IAGP
HPO
ORPHA:99798
NCBI chr14:36,657,568...36,679,362
Ensembl chr14:36,657,568...36,679,362
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PPP2R5D
protein phosphatase 2 regulatory subunit B'delta
IAGP
HPO
ORPHA:457279
NCBI chr 6:42,984,570...43,012,342
Ensembl chr 6:42,984,553...43,012,342
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PTPN22
protein tyrosine phosphatase non-receptor type 22
IAGP
HPO
ORPHA:397
NCBI chr 1:113,813,811...113,871,759
Ensembl chr 1:113,813,811...113,871,753
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PYGM
glycogen phosphorylase, muscle associated
IAGP
HPO
ORPHA:368
NCBI chr11:64,746,389...64,760,715
Ensembl chr11:64,746,389...64,759,974
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PYROXD1
pyridine nucleotide-disulphide oxidoreductase domain 1
IAGP
HPO
OMIM:617258
NCBI chr12:21,437,655...21,471,250
Ensembl chr12:21,437,615...21,471,250
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SELENON
selenoprotein N
IAGP
HPO
ORPHA:2020
NCBI chr 1:25,800,193...25,818,221
Ensembl chr 1:25,800,193...25,818,221
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SLC39A14
solute carrier family 39 member 14
IAGP
HPO
OMIM:617013
NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,278...22,434,129
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SUMO1
small ubiquitin like modifier 1
IAGP
HPO
ORPHA:99798
NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
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TGFA
transforming growth factor alpha
IAGP
HPO
ORPHA:99798
NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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TP63
tumor protein p63
IAGP
HPO
ORPHA:141291
NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
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TPM2
tropomyosin 2
IAGP
HPO
ORPHA:2020
NCBI chr 9:35,681,993...35,690,056
Ensembl chr 9:35,681,992...35,690,056
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TPM3
tropomyosin 3
IAGP
HPO
ORPHA:2020
NCBI chr 1:154,155,308...154,192,100
Ensembl chr 1:154,155,308...154,194,648
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TUBB3
tubulin beta 3 class III
IAGP
HPO
ORPHA:300570
NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
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WNT10A
Wnt family member 10A
IAGP
HPO
ORPHA:99798
NCBI chr 2:218,874,116...218,893,928
Ensembl chr 2:218,880,852...218,899,581
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WNT10B
Wnt family member 10B
IAGP
HPO
ORPHA:99798
NCBI chr12:48,965,340...48,971,735
Ensembl chr12:48,965,340...48,971,735
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