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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Abnormality of bone mineral density
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Accession:HP:0004348 term browser browse the term
Definition:This term applies to all changes in bone mineral density which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone. Changes may affect all bones of the organism, just certain bones or only parts of bones and include decreased mineralisation as may be seen in osteoporosis or increased mineralisation and or ossification as in osteopetrosis, exostoses or any kind of atopic calicfications of different origin and distribution. The overall amount of mineralization of the bone-organ can be measured as the amount of matter per cubic centimeter of bones, usually measured by densitometry of the lumbar spine or hip. The measurements are usually reported as g/cm3 or as a Z-score (the number of standard deviations above or below the mean for the patient's age and sex). Note that measurement with this method does not reflect local changes in other bones, and as such might not be correct with regard the hole bone-organ.
Synonyms:exact_synonym: Abnormality of bone mineralisation and ossification
 xref: UMLS:C4021657

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Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the skeletal system 0
          Abnormal skeletal morphology 0
            Abnormal bone structure 0
              Abnormal bone ossification 0
                Abnormality of bone mineral density 0
                  Abnormal tarsal bone mineral density + 0
                  Increased bone mineral density + 0
                  Patchy changes of bone mineral density + 0
                  Precocious costochondral ossification 0
                  Reduced bone mineral density + 0
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