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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Centrally nucleated skeletal muscle fibers
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Accession:HP:0003687 term browser browse the term
Definition:An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells).
Comment:Normally, the nuclei of muscle cells are located peripherally, immediately under the plasma membrane (sarcolemma).
Synonyms:exact_synonym: Central nuclei;   Centralised nuclei;   Centralised sarcomeric nuclei;   Centralized nuclei;   Centralized sarcomeric nuclei;   Centrally nucleated skeletal muscle fibres
 xref: UMLS:C1842170

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the musculature 0
          Abnormal skeletal muscle morphology 0
            Abnormal muscle fiber morphology 0
              Centrally nucleated skeletal muscle fibers 0
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