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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Onion bulb formation
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Accession:HP:0003383 term browser browse the term
Definition:Repeated episodes of segmental demyelination and remyelination lead to the accumulation of supernumerary Schwann cells around axons, which is referred to as onion bulb formation. This finding affects peripheral nerves.
Comment:This feature is characteristic of chronic demyelinating neuropathies as well as certain hereditary neuropathies. Onion-bulb formation may be observed in electron microscopic examinations of peripheral nerve biopsy material. Often, this examination is performed on the sural nerve.
Synonyms:related_synonym: ONION BULB FORMATIONS
 alt_id: HP:0003389;   HP:0007013;   HP:0007022;   HP:0007084;   HP:0008276
 xref: UMLS:C1847906


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Abnormal myelination 0
            Abnormal peripheral myelination 0
              Onion bulb formation 0
                Basal lamina onion bulb formation 0
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