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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Impaired lymphocyte transformation with phytohemagglutinin
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Accession:HP:0003347 term browser browse the term
Definition:Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes.
Comment:The response of lymphocytes to PHA is measured by their ability to transform and to undergo mitosis.
Synonyms:xref: UMLS:C4025625


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormal leukocyte morphology 0
          Abnormal lymphocyte morphology 0
            Impaired lymphocyte transformation with phytohemagglutinin 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormal immune system morphology 0
          Abnormal cellular immune system morphology 0
            Abnormal leukocyte morphology 0
              Abnormal lymphocyte morphology 0
                Impaired lymphocyte transformation with phytohemagglutinin 0
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